Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-Ku, Seoul 135-710, Republic of Korea.
Eur J Radiol. 2011 Nov;80(2):526-32. doi: 10.1016/j.ejrad.2009.11.011. Epub 2009 Dec 11.
The purposes of this study are to evaluate the ex vivo and in vivo efficacy of radiofrequency ablation (RFA) on different porcine tissues by the ablation of three different sites simultaneously.
A multichannel RFA system, enables three separate tumors to be ablated simultaneously, was used. RFA procedures were applied to normal porcine liver, kidney, and muscle together ex vivo (n=12) and in vivo (n=17). Pre-impedances, defined as baseline systemic impedances of tissues before beginning RFA, and the areas of ablation zones were measured and compared.
The areas of ablation zones among three organs had a significant difference in decreasing order as follows: liver, muscle, and kidney in the ex vivo study (p=0.001); muscle, liver, and kidney in the in vivo study (p<0.0001). The areas of ablation zones between ex vivo and in vivo had a significant difference in the liver and muscle (each p<0.05). There was no significant correlation between the areas of ablation zones and pre-impedances in both studies.
Renal RFA produced the smallest ablation zone in both in vivo and ex vivo studies. Muscular RFA demonstrated the largest ablation zone in the in vivo study, and hepatic RFA showed the largest ablation zone in the ex vivo study. This variability in the tissues should be considered for performing an optimized RFA for each organ site.
本研究旨在通过同时消融三个不同部位来评估射频消融（RFA）对不同猪组织的离体和体内疗效。
使用一种多通道 RFA 系统，可同时消融三个单独的肿瘤。离体（n=12）和体内（n=17）研究中，对正常猪的肝、肾和肌肉同时进行 RFA 处理。测量并比较了预阻抗（定义为开始 RFA 前组织的基础全身阻抗）和消融区域面积。
离体研究中三个器官的消融区域面积依次递减，按降序排列如下：肝、肌肉、肾（p=0.001）；体内研究中，肌肉、肝、肾（p<0.0001）。离体和体内研究中，肝和肌肉的消融区域面积有显著差异（p<0.05）。在两项研究中，消融区域面积与预阻抗之间均无显著相关性。
在体内和离体研究中，肾 RFA 产生的消融区域最小。体内研究中肌肉 RFA 的消融区域最大，离体研究中肝 RFA 的消融区域最大。对于每个器官部位，应考虑组织的这种变异性来进行优化的 RFA。
