成骨不全症患者的软骨 II 型胶原蛋白降解增加，可作为骨 I 型胶原蛋白改变的人类模型。

Increased cartilage type II collagen degradation in patients with osteogenesis imperfecta used as a human model of bone type I collagen alterations.

机构信息

INSERM Research Unit 831, Université de Lyon, Lyon, France.

出版信息

Bone. 2010 Apr;46(4):897-900. doi: 10.1016/j.bone.2009.12.003. Epub 2009 Dec 11.

DOI:10.1016/j.bone.2009.12.003

PMID:20005316

Abstract

OBJECTIVE

We investigated whether cartilage degradation is altered in adult patients with mild osteogenesis imperfecta (OI) used as a human model of bone type I collagen-related osteoarthritis (OA).

PATIENTS AND METHODS

Sixty-four adult patients with OI (39% women, mean age+/-SD: 37+/-12 years) and 64 healthy age-matched controls (54% women, 39+/-7 years) were included. We also compared data in 87 patients with knee OA (73% women, 63+/-8 years, mean disease duration: 6 years) and 291 age-matched controls (80% women, 62+/-10 years). Urinary C-terminal cross-linked telopeptide of type II collagen (CTX-II), a marker of cartilage degradation, urinary helical peptide of type I collagen (Helix-I), a marker of bone resorption, and the urinary ratio between non-isomerised/isomerised (alpha/beta CTX-I) type I collagen C-telopeptide, a marker of type I collagen maturation, were measured.

RESULTS

Patients with OI had CTX-II levels similar to those of subjects with knee OA (p=0.89; mean+/-SEM; 460+/-57 ng/mmol Cr for OI group and 547+/-32 ng/mmol Cr for OA group) and significantly higher than both young (144+/-7.8 ng/mmol Cr, p<0.0001) and old controls (247+/-7 ng/mmol Cr, p<0.0001). In patients with OI, increased Helix-I (p<0.0001) and alpha/beta CTX-I (p=0.0067) were independently associated with increased CTX-II and together explained 26% of its variance (p< 0.0001). In patients with knee OA, increased levels of alpha/beta CTX-I ratio were also associated with higher CTX-II levels.

CONCLUSION

Adult patients with OI or knee OA are characterized by increased cartilage type II collagen degradation, which is associated with increased type I collagen degradation for OI and lower type I collagen maturation for both OI and OA. These data suggest that both quantitative and qualitative alterations of bone type I collagen metabolism are involved in increased cartilage degradation in patients with OI or knee OA.

摘要

目的

我们研究了轻度成骨不全症（OI）患者的软骨降解是否发生改变，OI 患者被用作骨 I 型胶原相关骨关节炎（OA）的人类模型。

方法

纳入 64 名成年 OI 患者（39%为女性，平均年龄+/-标准差：37+/-12 岁）和 64 名年龄匹配的健康对照者（54%为女性，39+/-7 岁）。我们还比较了 87 名膝关节 OA 患者（73%为女性，63+/-8 岁，平均病程：6 年）和 291 名年龄匹配的对照者（80%为女性，62+/-10 岁）的数据。我们检测了尿型 II 胶原 C 端交联肽（CTX-II）、软骨降解标志物、尿 I 型胶原螺旋肽（Helix-I）、骨吸收标志物、以及非异构化/异构化（alpha/beta CTX-I）I 型胶原 C 端肽的尿比值，后者是 I 型胶原成熟的标志物。

结果

OI 患者的 CTX-II 水平与膝关节 OA 患者相似（p=0.89；平均值+/-SEM；OI 组为 460+/-57 ng/mmol Cr，OA 组为 547+/-32 ng/mmol Cr），明显高于年轻（144+/-7.8 ng/mmol Cr，p<0.0001）和老年对照者（247+/-7 ng/mmol Cr，p<0.0001）。在 OI 患者中，升高的 Helix-I（p<0.0001）和 alpha/beta CTX-I（p=0.0067）与升高的 CTX-II 独立相关，共同解释了其变异的 26%（p<0.0001）。在膝关节 OA 患者中，alpha/beta CTX-I 比值的升高也与更高的 CTX-II 水平相关。