Marcon Nathalie, Bressenot Aude, Montagne Karine, Bastien Claire, Champigneulle Jacqueline, Monhoven Nathalie, Albuisson Eliane, Plénat François
Equipe d'accueil signalisation et génomique fonctionnelle en recherche translationnelle oncologique, service d'anatomie et cytologie pathologiques, hôpitaux de Brabois, CHU de Nancy, université de Nancy, 5, allée du Morvan, 54511 Vandoeuvre-lès-Nancy, France.
Ann Pathol. 2009 Dec;29(6):460-7. doi: 10.1016/j.annpat.2009.09.011.
The quest for formaldehyde substitutes is motivated by two fundamental developments: the OSHA regulation standard declaring it hazardous and advocating its substitution with less dangerous chemicals and the fact that formalin is a poor preserver of nucleic acids. Among the non-alcoholic formalin substitute, glyoxal has been hailed as the best alternative. In this work, we showed that glyoxal-containing fixatives are not plausible polyvalent substitution options.
职业安全与健康管理局（OSHA）的监管标准宣布甲醛具有危险性，并提倡用危险性较小的化学品替代它；以及福尔马林对核酸的保存效果不佳这一事实。在非酒精性福尔马林替代品中，乙二醛被誉为最佳选择。在这项研究中，我们表明含乙二醛的固定剂并非合理的多价替代选择。
