School of Computing, University of Kent, Canterbury CT2 7NF, UK.
J R Soc Interface. 2010 Jun 6;7(47):945-54. doi: 10.1098/rsif.2009.0474. Epub 2009 Dec 9.
We analyse the trade-off between the speed with which a gene can propagate information, the noise of its output and its metabolic cost. Our main finding is that for any given level of metabolic cost there is an optimal trade-off between noise and processing speed. Any system with a non-vanishing leak expression rate is suboptimal, i.e. it will exhibit higher noise and/or slower speed than leak-free systems with the same metabolic cost. We also show that there is an optimal Hill coefficient h which minimizes noise and metabolic cost at fixed speeds, and an optimal threshold K which minimizes noise.
我们分析了基因在传播信息的速度、输出的噪声和代谢成本之间的权衡。我们的主要发现是，对于任何给定的代谢成本水平，噪声和处理速度之间都存在最佳的权衡。任何具有非零泄漏表达率的系统都是次优的，即与具有相同代谢成本的无泄漏系统相比，它将表现出更高的噪声和/或更慢的速度。我们还表明，存在一个最优的 Hill 系数 h，它在固定速度下最小化噪声和代谢成本，以及一个最优的阈值 K，它最小化噪声。
