补骨脂素灭活的1型登革病毒候选疫苗在小鼠体内的免疫原性。
Immunogenicity of a psoralen-inactivated dengue virus type 1 vaccine candidate in mice.
作者信息
Maves Ryan C, Castillo Oré Roger M, Porter Kevin R, Kochel Tadeusz J
机构信息
U.S. Naval Medical Research Center Detachment, Lima, Peru.
出版信息
Clin Vaccine Immunol. 2010 Feb;17(2):304-6. doi: 10.1128/CVI.00353-09. Epub 2009 Dec 9.
Abstract
We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.
摘要
我们在小家鼠中评估了一种新型补骨脂素灭活的1型登革病毒（DENV-1）候选疫苗。小鼠接受皮内注射明矾或5至10纳克补骨脂素灭活病毒。在90天时，11只接受10纳克剂量的小鼠中有10只检测到抗DENV-1中和抗体。补骨脂素灭活的DENV-1在小鼠中具有免疫原性。
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