Le Marchand L, Hankin J H, Kolonel L N, Wilkens L R
Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813.
Am J Epidemiol. 1991 Feb 1;133(3):215-9. doi: 10.1093/oxfordjournals.aje.a115865.
This is a further analysis of a case-control study of 452 prostate cancer cases and 899 population controls that was conducted in 1970-1983 among the multiethnic population of Hawaii. Because a previous analysis had shown a positive association with intake of beta-carotene, a nutrient presently being tested for chemoprevention, the authors reexamined the data for consistency among the main food sources of beta-carotene. Vegetables and fruits containing other phytochemicals suspected to be cancer inhibitors were also examined. With the exception of papaya, which was positively associated with risk among men aged 70 years and older, consumption of other yellow-orange fruits and vegetables, tomatoes, dark green vegetables, and cruciferous vegetables was not associated with prostate cancer risk. These results suggest that: 1) the positive association with beta-carotene intake among older men that the authors previously reported was essentially due to the greater papaya consumption of cases compared with controls; and 2) intake of beta-carotene, lycopene, lutein, indoles, phenols, or other phytochemicals is not associated with prostate cancer risk.
这是一项病例对照研究的进一步分析，该研究于1970年至1983年在夏威夷的多民族人群中开展，涉及452例前列腺癌病例和899名人群对照。由于之前的一项分析显示，其与β-胡萝卜素的摄入量呈正相关，β-胡萝卜素是一种目前正在进行化学预防试验的营养素，因此作者重新检查了数据，以确定β-胡萝卜素的主要食物来源之间的一致性。还对含有其他疑似癌症抑制物的植物化学物质的蔬菜和水果进行了检查。除了番木瓜与70岁及以上男性的患病风险呈正相关外，其他橙黄色水果和蔬菜、西红柿、深绿色蔬菜和十字花科蔬菜的摄入量与前列腺癌风险无关。这些结果表明：1）作者之前报告的老年男性β-胡萝卜素摄入量与患病风险呈正相关，主要是因为病例组比对照组食用了更多的番木瓜；2）β-胡萝卜素、番茄红素、叶黄素、吲哚、酚类或其他植物化学物质的摄入量与前列腺癌风险无关。
