Huxley Rachel, Lee Crystal Man Ying, Barzi Federica, Timmermeister Leif, Czernichow Sebastien, Perkovic Vlado, Grobbee Diederick E, Batty David, Woodward Mark
The George Institute for International Health, The University of Sydney, Australia.
Arch Intern Med. 2009 Dec 14;169(22):2053-63. doi: 10.1001/archinternmed.2009.439.
Coffee consumption has been reported to be inversely associated with risk of type 2 diabetes mellitus. Similar associations have also been reported for decaffeinated coffee and tea. We report herein the findings of meta-analyses for the association between coffee, decaffeinated coffee, and tea consumption with risk of diabetes.
Relevant studies were identified through search engines using a combined text word and MeSH (Medical Subject Headings) search strategy. Prospective studies that reported an estimate of the association between coffee, decaffeinated coffee, or tea with incident diabetes between 1966 and July 2009.
Data from 18 studies with information on 457 922 participants reported on the association between coffee consumption and diabetes. Six (N = 225 516) and 7 studies (N = 286 701) also reported estimates of the association between decaffeinated coffee and tea with diabetes, respectively. We found an inverse log-linear relationship between coffee consumption and subsequent risk of diabetes such that every additional cup of coffee consumed in a day was associated with a 7% reduction in the excess risk of diabetes relative risk, 0.93 [95% confidence interval, 0.91-0.95]) after adjustment for potential confounders.
Owing to the presence of small-study bias, our results may represent an overestimate of the true magnitude of the association. Similar significant and inverse associations were observed with decaffeinated coffee and tea and risk of incident diabetes. High intakes of coffee, decaffeinated coffee, and tea are associated with reduced risk of diabetes. The putative protective effects of these beverages warrant further investigation in randomized trials.
据报道，咖啡摄入量与2型糖尿病风险呈负相关。对于脱咖啡因咖啡和茶，也有类似的关联报道。我们在此报告咖啡、脱咖啡因咖啡和茶的摄入量与糖尿病风险之间关联的荟萃分析结果。
通过搜索引擎，采用文本词与医学主题词（MeSH）相结合的搜索策略来识别相关研究。纳入1966年至2009年7月期间报告了咖啡、脱咖啡因咖啡或茶与新发糖尿病之间关联估计值的前瞻性研究。
18项研究的数据提供了457922名参与者关于咖啡摄入量与糖尿病之间关联的信息。另外，分别有6项研究（N = 225516）和7项研究（N = 286701）报告了脱咖啡因咖啡和茶与糖尿病之间关联的估计值。我们发现咖啡摄入量与随后患糖尿病的风险呈负对数线性关系，即调整潜在混杂因素后，每天多喝一杯咖啡与糖尿病额外风险降低7%相关（相对风险，0.93 [95%置信区间，0.91 - 0.95]）。
由于存在小型研究偏差，我们的结果可能高估了该关联的真实强度。对于脱咖啡因咖啡和茶与新发糖尿病风险之间，也观察到了类似的显著负相关。大量摄入咖啡、脱咖啡因咖啡和茶与糖尿病风险降低相关。这些饮品的假定保护作用值得在随机试验中进一步研究。
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