Stein Joshua D, Zacks David N, Grossman Daniel, Grabe Hilary, Johnson Mark W, Sloan Frank A
Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall St, Ann Arbor, MI 48105, USA.
Arch Ophthalmol. 2009 Dec;127(12):1656-63. doi: 10.1001/archophthalmol.2009.300.
To assess the complication rates of pars plana vitrectomy (PPV) among older Americans and to determine whether rates of adverse events and additional operations have changed during the past decade.
Claims data were reviewed to identify all adults aged 68 years or older in the 5% Medicare sample who underwent their first PPV during 1994-1995, 1999-2000, and 2004-2005. One-year rates of severe complications (endophthalmitis, suprachoroidal hemorrhage, or retinal detachment), less severe complications, receipt of an additional operation, and blindness were calculated and compared among the 3 groups using Cox regression. Analyses were adjusted for prior adverse events (during the previous 3 years), demographic characteristics, and comorbid conditions.
The 1994-1995, 1999-2000, and 2004-2005 cohorts had 3263, 5064, and 5263 patients, respectively. The 1-year severe complication rates did not differ among the 3 groups (range, 4.8%-5.5%). The hazard of a less severe complication or an additional operation was higher in the 2004-2005 cohort than in the earlier cohorts (P < .05 for all comparisons). The hazard of endophthalmitis was higher in black individuals (P = .07) and those of other races (P = .02) than in white patients.
During the past decade, rates of severe complications after PPV remained stable, but rates of less severe complications and subsequent operations increased. Future studies should explore the potential factors that explain these changes and the alarming elevated incidence of post-PPV endophthalmitis among nonwhite individuals.
评估美国老年人行玻璃体切割术(PPV)的并发症发生率,并确定过去十年中不良事件和额外手术的发生率是否发生了变化。
回顾索赔数据,以识别1994 - 1995年、1999 - 2000年和2004 - 2005年期间在5%医疗保险样本中接受首次PPV的所有68岁及以上成年人。计算三组中严重并发症(眼内炎、脉络膜上腔出血或视网膜脱离)、较轻微并发症、接受额外手术和失明的一年发生率,并使用Cox回归进行比较。分析针对既往不良事件(前3年期间)、人口统计学特征和合并症进行了调整。
1994 - 1995年、1999 - 2000年和2004 - 2005年队列分别有3263例、5064例和5263例患者。三组的1年严重并发症发生率无差异(范围为4.8% - 5.5%)。2004 - 2005年队列中较轻微并发症或额外手术的风险高于早期队列(所有比较P < 0.05)。黑人个体(P = 0.07)和其他种族个体(P = 0.02)发生眼内炎的风险高于白人患者。
在过去十年中,PPV后严重并发症的发生率保持稳定,但较轻微并发症和后续手术的发生率有所增加。未来的研究应探索解释这些变化的潜在因素,以及非白人个体中PPV后眼内炎发生率惊人上升的原因。