新型真菌（单端孢霉）播散性感染的小鼠模型及泊沙康唑的成功治疗。
Murine model of a disseminated infection by the novel fungus Fonsecaea monophora and successful treatment with posaconazole.
机构信息
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
出版信息
Antimicrob Agents Chemother. 2010 Feb;54(2):919-23. doi: 10.1128/AAC.01284-09. Epub 2009 Dec 14.
Abstract
We have evaluated the efficacy of posaconazole, amphotericin B, and itraconazole in a murine model of disseminated infection by Fonsecaea monophora. Of these three antifungal drugs tested, posaconazole prolonged survival significantly and reduced the fungal load in most of the organs tested. Bioassay studies demonstrated the relationship between posaconazole levels and dose escalation in serum and brain tissue. Posaconazole may have a clinical role in the treatment of disseminated infections by F. monophora.
摘要
我们评估了泊沙康唑、两性霉素 B 和伊曲康唑在毛孢子菌属（Fonsecaea monophora）播散性感染的小鼠模型中的疗效。在这三种测试的抗真菌药物中，泊沙康唑显著延长了生存时间，降低了大多数测试器官中的真菌负荷。生物测定研究表明了泊沙康唑水平与血清和脑组织中剂量递增之间的关系。泊沙康唑在治疗毛孢子菌属（Fonsecaea monophora）播散性感染方面可能具有临床作用。
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