鉴定一株猪源耐甲氧西林金黄色葡萄球菌 ST398 株中携带 erm(T)、dfrK 和 tet(L)耐药基因的质粒耐药基因簇。
Identification of a plasmid-borne resistance gene cluster comprising the resistance genes erm(T), dfrK, and tet(L) in a porcine methicillin-resistant Staphylococcus aureus ST398 strain.
机构信息
Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut (FLI), Höltystr. 10, 31535 Neustadt-Mariensee, Germany.
出版信息
Antimicrob Agents Chemother. 2010 Feb;54(2):915-8. doi: 10.1128/AAC.01091-09. Epub 2009 Dec 14.
Abstract
A novel plasmid-borne resistance gene cluster comprising the genes erm(T) for macrolide-lincosamide-streptogramin B resistance, dfrK for trimethoprim resistance, and tet(L) for tetracycline resistance was identified in a porcine methicillin-resistant Staphylococcus aureus sequence type 398 (ST398) strain. This erm(T)-dfrK-tet(L) region was flanked by copies of the novel IS element ISSau10. The erm(T) region resembled that of Streptococcus pyogenes plasmid pRW35. The erm(T) gene of pKKS25 was expressed constitutively due to a 57-bp deletion in the erm(T) translational attenuator.
摘要
在一株猪源耐甲氧西林金黄色葡萄球菌 398 型（ST398）分离株中发现了一个新型质粒携带的耐药基因簇，包含大环内酯-林可酰胺-链阳菌素 B 耐药基因 erm(T)、甲氧苄啶耐药基因 dfrK 和四环素耐药基因 tet(L)。该 erm(T)-dfrK-tet(L) 区域两侧为新型 IS 元件 ISSau10 的拷贝。 erm(T) 区域与化脓性链球菌质粒 pRW35 相似。pKKS25 的 erm(T) 基因由于 erm(T) 翻译衰减子中的 57bp 缺失而持续表达。
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