抑制血管内皮生长因子受体-1/Wnt/β-连环蛋白信号通路串扰可导致肿瘤细胞死亡。
Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death.
作者信息
Zeitlin Benjamin D, Ellis Lee M, Nör Jacques E
机构信息
Authors' Affiliations: Angiogenesis Research Laboratory, Department of Restorative Sciences, School of Dentistry; Department of Biomedical Engineering, College of Engineering; Department of Otolaryngology, School of Medicine, University of Michigan, Ann Arbor, Michigan; and Departments of Surgical Oncology and Cancer Biology, Maryland Anderson Cancer Center, University of Texas, Houston, Texas.
出版信息
Clin Cancer Res. 2009 Dec 15;15(24):7453-7455. doi: 10.1158/1078-0432.CCR-09-2578.
Abstract
Two genes are considered synthetic lethal if mutation of either alone allows cell viability, whereas simultaneous mutation leads to cell death. A synthetic lethal screen unveiled the dependency of Wnt/beta-catenin-addicted colorectal cancer cells on vascular endothelial growth factor receptor-1 kinase activity and suggested a novel therapeutic approach for this malignancy. (Clin Cancer Res 2009;15(24):7453-5).
摘要
如果单独一个基因发生突变时细胞仍可存活，而两个基因同时发生突变则导致细胞死亡，那么这两个基因被认为是合成致死基因。一项合成致死筛选揭示了对Wnt/β-连环蛋白成瘾的结肠癌细胞对血管内皮生长因子受体-1激酶活性的依赖性，并提示了针对这种恶性肿瘤的一种新的治疗方法。（《临床癌症研究》2009年；15(24):7453 - 7455）
相似文献
1
Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death.抑制血管内皮生长因子受体-1/Wnt/β-连环蛋白信号通路串扰可导致肿瘤细胞死亡。
Clin Cancer Res. 2009 Dec 15;15(24):7453-7455. doi: 10.1158/1078-0432.CCR-09-2578.
2
Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer.血管内皮生长因子受体-1对结肠癌中异常的β-连环蛋白激活具有合成致死性。
Clin Cancer Res. 2009 Dec 15;15(24):7529-7537. doi: 10.1158/1078-0432.CCR-09-0336.
3
Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/β-Catenin and PI3K/Akt Signaling.磷脂酶 D1 抑制与 ICAT 的上调有关，ICAT 阻断 Wnt/β-连环蛋白和 PI3K/Akt 信号通路的过度激活，抑制结直肠癌细胞生长。
Clin Cancer Res. 2017 Dec 1;23(23):7340-7350. doi: 10.1158/1078-0432.CCR-17-0749. Epub 2017 Sep 22.
4
A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1.一项激酶组siRNA筛选将HGS鉴定为CTNNB1发生致癌突变的肝癌的潜在靶点。
BMC Cancer. 2015 Dec 29;15:1020. doi: 10.1186/s12885-015-2037-8.
5
Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in -Mutant Acute Myeloid Leukemia.Wnt/β-连环蛋白信号通路的破坏可发挥抗白血病作用，并与 FLT3 抑制在 - 突变型急性髓系白血病中协同作用。
Clin Cancer Res. 2018 May 15;24(10):2417-2429. doi: 10.1158/1078-0432.CCR-17-1556. Epub 2018 Feb 20.
6
Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth.DepTOr 是 Wnt/β-catenin/c-Myc 的一个新靶点，并促进结直肠癌细胞生长。
Cancer Res. 2018 Jun 15;78(12):3163-3175. doi: 10.1158/0008-5472.CAN-17-3107. Epub 2018 Apr 17.
7
TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis.TRIB3 通过与β-catenin 和 TCF4 相互作用来增加结直肠癌细胞干细胞的干细胞特征和肿瘤发生。
Gastroenterology. 2019 Feb;156(3):708-721.e15. doi: 10.1053/j.gastro.2018.10.031. Epub 2018 Oct 24.
8
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression.内皮细胞 Wnt/β-连环蛋白信号通路通过诱导 PDGF-B 表达抑制胶质瘤血管生成并使肿瘤血管正常化。
J Exp Med. 2012 Aug 27;209(9):1611-27. doi: 10.1084/jem.20111580. Epub 2012 Aug 20.
9
Endothelial β-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression.内皮细胞 β-连环蛋白信号通过促进血管生成、尖端细胞形成和 VEGFR（血管内皮生长因子受体）2 表达来支持出生后大脑和视网膜血管生成。
Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2273-2288. doi: 10.1161/ATVBAHA.119.312749. Epub 2019 Sep 19.
10
Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury?慢性缩窄性损伤后眶下血神经屏障早期破坏是否与 Wnt/β-连环蛋白和 Sonic Hedgehog 通路之间的神经内膜内皮细胞串扰有关？
Mol Pain. 2017 Jan-Dec;13:1744806917727625. doi: 10.1177/1744806917727625.
引用本文的文献
1
Molecular landscape of clear cell renal cell carcinoma: targeting the Wnt/β-catenin signaling pathway.透明细胞肾细胞癌的分子图谱：靶向Wnt/β-连环蛋白信号通路
Discov Oncol. 2025 Apr 14;16(1):524. doi: 10.1007/s12672-025-02228-5.
2
Profiling and targeting cancer stem cell signaling pathways for cancer therapeutics.剖析并靶向癌症干细胞信号通路用于癌症治疗
Front Cell Dev Biol. 2023 May 25;11:1125174. doi: 10.3389/fcell.2023.1125174. eCollection 2023.
3
Neoadjuvant Treatment with Angiogenesis-Inhibitor Dovitinib Prior to Local Therapy in Hepatocellular Carcinoma: A Phase II Study.索拉非尼序贯多韦替尼治疗方案对比索拉非尼单药治疗晚期肝癌的随机、开放、平行对照、多中心 II 期临床研究
Oncologist. 2021 Oct;26(10):854-864. doi: 10.1002/onco.13901. Epub 2021 Aug 4.
4
Angiogenesis-Related Functions of Wnt Signaling in Colorectal Carcinogenesis.Wnt信号通路在结直肠癌发生发展中的血管生成相关功能
Cancers (Basel). 2020 Dec 2;12(12):3601. doi: 10.3390/cancers12123601.
5
MicroRNA-139-5p/Flt1/Wnt/β-catenin regulatory crosstalk modulates the progression of glioma.微小 RNA-139-5p/Flt1/Wnt/β-连环蛋白调控串扰调节胶质瘤的进展。
Int J Mol Med. 2018 Apr;41(4):2139-2149. doi: 10.3892/ijmm.2018.3439. Epub 2018 Jan 30.
6
Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer.Wnt3a 的表达与复发性或 IV 期结直肠癌原发灶和转移灶中 MMP-9 的表达相关。
BMC Cancer. 2014 Feb 24;14:125. doi: 10.1186/1471-2407-14-125.
7
Impact of an altered Wnt1/β-catenin expression on clinicopathology and prognosis in clear cell renal cell carcinoma.Wnt1/β-连环蛋白表达改变对透明细胞肾细胞癌临床病理及预后的影响
Int J Mol Sci. 2013 May 24;14(6):10944-57. doi: 10.3390/ijms140610944.
8
Telomeres and tissue engineering: the potential roles of TERT in VEGF-mediated angiogenesis.端粒与组织工程：TERT 在 VEGF 介导的血管生成中的潜在作用。
Stem Cell Rev Rep. 2012 Dec;8(4):1275-81. doi: 10.1007/s12015-012-9414-3.
9
miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1.miR-200 通过靶向 Flt1/VEGFR1 抑制肺腺癌细胞的侵袭和转移。
Mol Cancer Res. 2011 Jan;9(1):25-35. doi: 10.1158/1541-7786.MCR-10-0497. Epub 2010 Nov 29.
10
Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements.联合应用靶向癌症治疗药物：新方法和迫切需求。
Nat Rev Drug Discov. 2010 Nov;9(11):843-56. doi: 10.1038/nrd3216. Epub 2010 Oct 29.
本文引用的文献
1
Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer.血管内皮生长因子受体-1对结肠癌中异常的β-连环蛋白激活具有合成致死性。
Clin Cancer Res. 2009 Dec 15;15(24):7529-7537. doi: 10.1158/1078-0432.CCR-09-0336.
2
VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2.VEGF 依赖性肿瘤血管生成需要 VEGFR1 和 VEGFR2 的反向和相互调节。
Cell Death Differ. 2010 Mar;17(3):499-512. doi: 10.1038/cdd.2009.152. Epub 2009 Oct 16.
3
Wnt/beta-catenin signaling: components, mechanisms, and diseases.Wnt/β-连环蛋白信号传导：组成部分、机制及相关疾病
Dev Cell. 2009 Jul;17(1):9-26. doi: 10.1016/j.devcel.2009.06.016.
4
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.一项全基因组RNA干扰筛选鉴定出了与Ras癌基因的多种合成致死相互作用。
Cell. 2009 May 29;137(5):835-48. doi: 10.1016/j.cell.2009.05.006.
5
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.致癌性KRAS依赖性与人类癌细胞中STK33抑制之间的合成致死相互作用。
Cell. 2009 May 29;137(5):821-34. doi: 10.1016/j.cell.2009.03.017.
6
VEGFR1 receptor tyrosine kinase localization to the Golgi apparatus is calcium-dependent.血管内皮生长因子受体1（VEGFR1）受体酪氨酸激酶定位于高尔基体是依赖于钙的。
Exp Cell Res. 2009 Mar 10;315(5):877-89. doi: 10.1016/j.yexcr.2008.12.020. Epub 2009 Jan 6.
7
VEGF-targeted therapy: mechanisms of anti-tumour activity.血管内皮生长因子靶向治疗：抗肿瘤活性机制
Nat Rev Cancer. 2008 Aug;8(8):579-91. doi: 10.1038/nrc2403. Epub 2008 Jul 3.
8
Survival of cancer cells is maintained by EGFR independent of its kinase activity.癌细胞的存活由表皮生长因子受体（EGFR）维持，且与其激酶活性无关。
Cancer Cell. 2008 May;13(5):385-93. doi: 10.1016/j.ccr.2008.03.015.
9
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.小干扰RNA通过Toll样受体3实现不依赖序列和靶点的血管生成抑制
Nature. 2008 Apr 3;452(7187):591-7. doi: 10.1038/nature06765. Epub 2008 Mar 26.
10
Crosstalk between tumor cells and microenvironment via Wnt pathway in colorectal cancer dissemination.在结直肠癌转移过程中，肿瘤细胞与微环境之间通过Wnt信号通路的相互作用。
World J Gastroenterol. 2008 Mar 28;14(12):1823-7. doi: 10.3748/wjg.14.1823.
Zotero 插件