慢性阻塞性肺疾病和哮喘中的系统性炎症：与合并症的关系。

Systemic inflammation in chronic obstructive pulmonary disease and asthma: relation with comorbidities.

机构信息

Pulmonary Research Institute at Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, 22927 Grosshansdorf, Germany.

出版信息

Proc Am Thorac Soc. 2009 Dec;6(8):648-51. doi: 10.1513/pats.200906-053DP.

DOI:10.1513/pats.200906-053DP

PMID:20008868

Abstract

Markers of systemic inflammation have been shown to be elevated in blood of patients with chronic obstructive pulmonary disease (COPD) when compared with control subjects without COPD. The origin of systemic inflammation in COPD is unclear. COPD is often accompanied by other chronic diseases that are also associated with systemic inflammation, such as chronic heart failure, diabetes, and arteriosclerosis. Physical inactivity and metabolic syndrome are relevant conditions leading to systemic inflammation in the general population. Recent data indicate that physical inactivity and coexisting metabolic syndrome are also independently related to systemic inflammation in patients with COPD. Concerning asthma, only limited data about systemic inflammatory markers exist. Some studies found systemic inflammatory markers to be elevated in patients with nonallergic asthma and obese patients with asthma. Further research should elucidate the complex relationship between obstructive lung disease, coexisting conditions, systemic inflammation accompanying these different conditions, and the causative role of systemic inflammation for comorbidities in COPD and asthma.

摘要

与没有 COPD 的对照受试者相比，慢性阻塞性肺疾病（COPD）患者的血液中已显示出系统炎症标志物升高。COPD 中全身炎症的起源尚不清楚。COPD 常伴有其他慢性疾病，这些疾病也与全身炎症相关，如慢性心力衰竭、糖尿病和动脉硬化。身体活动减少和代谢综合征是导致普通人群全身炎症的相关疾病。最近的数据表明，身体活动减少和并存的代谢综合征也与 COPD 患者的全身炎症独立相关。关于哮喘，仅有关于全身炎症标志物的有限数据。一些研究发现，非过敏性哮喘患者和肥胖哮喘患者的全身炎症标志物升高。进一步的研究应阐明阻塞性肺疾病、并存疾病、伴随这些不同疾病的全身炎症以及全身炎症对 COPD 和哮喘合并症的因果作用之间的复杂关系。