克服纺锤体检查点中的抑制作用。
Overcoming inhibition in the spindle checkpoint.
作者信息
Vanoosthuyse Vincent, Hardwick Kevin G
机构信息
Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom.
出版信息
Genes Dev. 2009 Dec 15;23(24):2799-805. doi: 10.1101/gad.1882109.
Abstract
Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.
摘要
纺锤体检查点沉默是有丝分裂过程中启动染色体分离的关键步骤，但令人惊讶的是，其机制鲜为人知。蛋白磷酸酶I（PP1）最近被证明是这一过程中的关键因子，在本期《基因与发育》中，秋吉及其同事（第2887 - 2899页）确定出芽酵母Fin1p是一种定位于动粒的PP1针对检查点靶标的活性调节因子。在此，我们综述了最近的机制见解，并提出了一个纺锤体检查点沉默的工作模型。
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本文引用的文献
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Genes Dev. 2009 Dec 15;23(24):2887-99. doi: 10.1101/gad.1865909.
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UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.UBE2S延长后期促进复合体/细胞周期体（APC/C）底物上的泛素链以促进有丝分裂退出。
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