我如何治疗血液恶性肿瘤患者的流感。
How I treat influenza in patients with hematologic malignancies.
机构信息
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
出版信息
Blood. 2010 Feb 18;115(7):1331-42. doi: 10.1182/blood-2009-11-255455. Epub 2009 Dec 15.
Abstract
The 2009 H1N1 influenza pandemic has heightened the interest of clinicians for options in the prevention and management of influenza virus infection in immunocompromised patients. Even before the emergence of the novel 2009 H1N1 strain, influenza disease was a serious complication in patients with hematologic malignancies receiving chemotherapy or undergoing hematopoietic cell transplantation. Here we review the clinical manifestations of seasonal and 2009 H1N1 influenza and discuss current diagnosis, antiviral treatment, and prophylaxis options. We also summarize infection control and vaccination strategies for patients, family members, and caregivers.
摘要
2009 年甲型 H1N1 流感大流行提高了临床医生对免疫功能低下患者预防和治疗流感病毒感染选择的兴趣。甚至在新型 2009 年甲型 H1N1 病毒株出现之前，接受化疗或造血细胞移植的血液恶性肿瘤患者流感疾病就是一种严重的并发症。在这里，我们回顾了季节性流感和 2009 年甲型 H1N1 流感的临床表现，并讨论了目前的诊断、抗病毒治疗和预防选择。我们还总结了针对患者、家庭成员和护理人员的感染控制和疫苗接种策略。
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