Faculty of Health Sciences, The University of Sydney, Sydney, Australia.
Med Sci Sports Exerc. 2010 Jan;42(1):23-34. doi: 10.1249/MSS.0b013e3181b07a31.
This study investigated the effects of high-intensity progressive resistance training (PRT) and high-intensity cycling (cycling) on muscle performance and the time course of strength gains in a chronic stroke population.
Forty-eight individuals with chronic stroke sequelae (mean +/- SD; age = 63 +/- 9 yr, time since stroke = 57 +/- 54 months) were randomly allocated to one of four treatment groups: PRT + cycling, PRT + sham cycling, sham PRT + cycling, or sham PRT + sham cycling groups in a fully factorial clinical trial. Thirty exercise sessions were conducted over a 10- to 12-wk period. The main outcomes investigated were measures of unilateral muscle strength, peak power, and muscle endurance.
Those undergoing PRT improved their lower limb muscle strength, peak power, and endurance compared with participants receiving sham PRT or cycling only (P < 0.05), and combined exercise was not superior to PRT alone. Strength improvements occurred primarily during the first 6 to 8 wk (98%-100% of total gain) and then reached a plateau during the final 2 to 4 wk.
We have shown for the first time in a direct comparison study that high-intensity PRT, but not cycling or sham exercise, can improve muscle strength, peak power, and muscle endurance in both affected and unaffected lower limbs after chronic stroke by a significant and clinically meaningful amount. Although strength gains plateaued earlier than anticipated, adherence to the intended continuous high-intensity progressive overload protocol was largely achieved (average load of 84% +/- 4% of one repetition maximum).
本研究旨在探讨高强度渐进式抗阻训练（PRT）和高强度骑行（骑行）对慢性中风患者肌肉性能和力量增益时间进程的影响。
48 名患有慢性中风后遗症的个体（平均值±SD；年龄=63±9 岁，中风后时间=57±54 个月）被随机分配到四个治疗组之一：PRT+骑行、PRT+假骑行、假 PRT+骑行或假 PRT+假骑行组，进行完全因子临床试验。在 10-12 周的时间内进行了 30 次运动。主要研究结果为单侧肌肉力量、峰值功率和肌肉耐力的测量值。
接受 PRT 的患者与接受假 PRT 或仅骑行的患者相比，下肢肌肉力量、峰值功率和耐力均得到改善（P<0.05），且联合运动并不优于单独 PRT。力量的改善主要发生在最初的 6 至 8 周（总增益的 98%-100%），然后在最后 2 至 4 周达到平台期。
我们首次在一项直接比较研究中表明，高强度 PRT 而非骑行或假运动可以通过显著且具有临床意义的幅度改善慢性中风后双侧下肢的肌肉力量、峰值功率和肌肉耐力。尽管力量增益比预期更早达到平台期，但对预期的连续高强度渐进性超负荷方案的依从性在很大程度上得以实现（平均负荷为 1 次重复最大值的 84%±4%）。
