(3R, 9R, 10R)-人参三醇：一种基于分子的营养保健品，可能应用于癌症预防和治疗。
(3R, 9R, 10R)-Panaxytriol: A molecular-based nutraceutical with possible application to cancer prevention and treatment.
作者信息
Ng Fay, Yun Heedong, Lei Xiaoguang, Danishefsky Samuel J, Fahey Jed, Stephenson Katherine, Flexner Charles, Lee Lawrence
机构信息
Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA.
出版信息
Tetrahedron Lett. 2008 Dec 8;49(50):7178-7179. doi: 10.1016/j.tetlet.2008.09.169.
Abstract
Panaxytriol is a nutraceutical-based active constituent of Korean red ginseng and is reported to exhibit potent anti-tumor properties. Its activity may be in part due to its induction of phase 2 chemoprotective enzymes. Its unique properties may have important implications in cancer therapeutics.
摘要
人参三醇是韩国红参中一种基于营养保健品的活性成分，据报道具有强大的抗肿瘤特性。其活性可能部分归因于它对2期化学保护酶的诱导作用。其独特性质可能在癌症治疗中具有重要意义。
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本文引用的文献
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Org Lett. 2008 Jan 17;10(2):257-9. doi: 10.1021/ol702651s. Epub 2007 Dec 13.
2
Small molecule natural products in the discovery of therapeutic agents: the synthesis connection.治疗药物发现中的小分子天然产物：合成方面的联系
J Org Chem. 2006 Oct 27;71(22):8329-51. doi: 10.1021/jo0610053.
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Total synthesis as a resource in drug discovery: the first in vivo evaluation of panaxytriol and its derivatives.全合成作为药物发现的一种资源：人参三醇及其衍生物的首次体内评价。
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