Medina Eva
Infection Immunology Research Group, Department of Microbial Pathogenesis, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Methods Mol Biol. 2010;602:405-10. doi: 10.1007/978-1-60761-058-8_22.
Respiratory tract infections remain among the most common clinical problems worldwide. Pneumonia or inflammation of the lungs can be caused by infection with bacteria, viruses, and other organisms. Pneumonia management has been challenged by the widespread distribution of antibiotic-resistant strains of Streptococcus pneumoniae, the commonest cause of community acquired pneumonia. Experimental models of pneumonia have played a crucial role for testing the efficacy of antimicrobial agents as well as for gaining a better understanding of the disease pathogenesis. These models have also received increased attention as tools for deriving pharmacodynamic data and for determining the clinical significance of drug resistance.
呼吸道感染仍然是全球最常见的临床问题之一。肺炎或肺部炎症可能由细菌、病毒和其他生物体感染引起。肺炎的治疗一直受到肺炎链球菌抗生素耐药菌株广泛传播的挑战，肺炎链球菌是社区获得性肺炎最常见的病因。肺炎的实验模型在测试抗菌药物的疗效以及更好地理解疾病发病机制方面发挥了关键作用。这些模型作为获取药效学数据和确定耐药性临床意义的工具也受到了越来越多的关注。
