Mullaney Ronan, Murphy Declan
Department of Psychiatry, Research and Education Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.
Dev Disabil Res Rev. 2009;15(4):279-83. doi: 10.1002/ddrr.87.
Neuroimaging studies of Turner syndrome can advance our understanding of the X chromosome in brain development, and the modulatory influence of endocrine factors. There is increasing evidence from neuroimaging studies that TX individuals have significant differences in the anatomy, function, and metabolism of a number of brain regions; including the parietal lobe; cerebellum, amygdala, hippocampus; and basal ganglia; and perhaps differences in "connectivity" between frontal and parieto-occipital regions. Finally, there is preliminary evidence that genomic imprinting, sex hormones and growth hormone have significant modulatory effects on brain maturation in TS.
对特纳综合征的神经影像学研究能够增进我们对大脑发育过程中X染色体以及内分泌因素调节作用的理解。神经影像学研究提供了越来越多的证据表明，特纳综合征患者在多个脑区的解剖结构、功能和代谢方面存在显著差异，这些脑区包括顶叶、小脑、杏仁核、海马体和基底神经节；而且额叶与顶枕叶区域之间的“连接性”可能也存在差异。最后，有初步证据表明，基因组印记、性激素和生长激素对特纳综合征患者的大脑成熟具有显著的调节作用。
