Davies-Coleman M T, Gustafson K R, Cantrell C L, Beutler J A, Pannell L K, Boyd M R
Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702-1201, USA.
J Nat Prod. 2000 Oct;63(10):1411-3. doi: 10.1021/np000158x.
Two new 3,6-epidioxy-7,10-tetrahydrofurano C(26) unsaturated fatty acids, stolonic acids A (1) and B (2), were isolated from a previously undescribed ascidian species, Stolonica sp. collected off the Maldive Islands in the Indian Ocean. The structures and relative stereochemistry of 1 and 2 were determined using conventional spectroscopic methods. Both compounds exhibited antiproliferative activity against selected human melanoma and ovarian tumor cell lines, with IC(50) values of approximately 0.05-0.1 microg/mL.
从印度洋马尔代夫群岛附近采集的一种此前未描述过的海鞘物种——Stolonica sp.中，分离出了两种新的3,6-环氧-7,10-四氢呋喃并C(26)不饱和脂肪酸，即斯托洛尼酸A（1）和B（2）。通过传统光谱方法确定了1和2的结构及相对立体化学。这两种化合物对选定的人黑素瘤和卵巢肿瘤细胞系均表现出抗增殖活性，IC(50)值约为0.05 - 0.1微克/毫升。
