Janus 激酶 2 抑制剂。一种新型稠合氮杂吲哚的合成与表征。
Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.
机构信息
Vertex Pharmaceuticals Inc., Cambridge, Massachusetts 02139-4242, USA.
出版信息
J Med Chem. 2009 Dec 24;52(24):7938-41. doi: 10.1021/jm901383u.
PMID:20014869
Abstract
The synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described. The compound is further evaluated for its ability to block the EPO/JAK2 signaling cascade in vitro and in vivo.
摘要
本发明公开了一种新型多环氮杂吲哚类衍生物的合成及表征，并描述了其与 JAK2 的结合。还进一步评价了该化合物在体外和体内阻断 EPO/JAK2 信号级联的能力。
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