Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724-5081, USA.
QJM. 2010 Apr;103(4):229-36. doi: 10.1093/qjmed/hcp176. Epub 2009 Dec 16.
The incidence of oropharyngeal cancers is rising worldwide in both nonsmokers and nondrinkers. Epidemiology studies suggest a strong association between human papillomavirus (HPV) 16 infection, changing sexual behavior and cancer development. Despite initial presentation with locally advanced disease and poorly differentiated histology, HPV-associated oropharyngeal carcinoma is associated with a good prognosis because its response to chemotherapy and radiation. Clinicians should be aware of the risk of oropharyngeal cancer in young people to avoid unnecessary delay in diagnosis and treatment. A history of oral sex should be elicited in young patients with enlarged neck nodes and/or tonsillar masses.
口咽癌在不吸烟和不饮酒者中的全球发病率正在上升。流行病学研究表明，人乳头瘤病毒（HPV）16 感染、性行为改变和癌症发展之间存在很强的关联。尽管最初表现为局部晚期疾病和低分化组织学，但 HPV 相关的口咽癌预后良好，因为其对化疗和放疗有反应。临床医生应该意识到年轻人患口咽癌的风险，以避免诊断和治疗的不必要延误。对于颈部淋巴结肿大和/或扁桃体肿大的年轻患者，应询问口交史。
