利用短相干光源可视化人眼锥状光感受器的变光学激活。
Variable optical activation of human cone photoreceptors visualized using a short coherence light source.
机构信息
Department of Ophthalmology, Medical College of Wisconsin, 925 North 87th Street,Milwaukee, Wisconsin 53226, USA.
出版信息
Opt Lett. 2009 Dec 15;34(24):3782-4. doi: 10.1364/OL.34.003782.
Abstract
It has been shown that after a visible stimulus, optical oscillations of nearly all cone photoreceptors can be observed using long coherence length light and in a few cones using short coherence length light. Here, we show that after exposure to a visible stimulus, a short coherence length imaging source reveals light-evoked oscillation signals in a large number of cones. More than 80% of cones in a given retinal area are activated (modulation in the reflectance signal) after stimulation, and the pattern of their activation can be subjectively classified into one of four categories. The application of light-evoked signal detection techniques for in vivo retinal imaging may prove useful for assessing the functional status of cones in normal and diseased retinae.
摘要
已经表明，使用长相干长度的光和在少数几个锥体中使用短相干长度的光，可以观察到几乎所有锥体光感受器的可见刺激后的光振荡。在这里，我们表明，在暴露于可见刺激之后，短相干长度成像源在大量锥体中揭示了光诱发的振荡信号。在给定的视网膜区域中，超过 80%的锥体在刺激后被激活（反射率信号的调制），并且它们的激活模式可以主观地分为四个类别之一。用于体内视网膜成像的光诱发信号检测技术的应用可能有助于评估正常和患病视网膜中锥体的功能状态。
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