Department of Nutritional Science and Food Management, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-gu, Seoul 120-750, Korea.
Nutr Res Pract. 2009 Spring;3(1):15-22. doi: 10.4162/nrp.2009.3.1.15. Epub 2009 Mar 31.
This study was performed to investigate the effect of chlorella on cadmium (Cd) toxicity in Cd- administered rats. Sixty male Sprague-Dawley rats (14 week-old) were blocked into 6 groups. Cadmium chloride was given at levels of 0 or 325 mg (Cd: 0, 160 ppm), and chlorella powder at levels of 0, 3 and 5%. Cadmium was accumulated in blood and tissues (liver, kidney and small intestine) in the Cd-exposed groups, while the accumulation of Cd was decreased in the Cd-exposed chlorella groups. Fecal and urinary Cd excretions were remarkably increased in Cd-exposed chlorella groups. Thus, cadmium retention ratio and absorption rate were decreased in the Cd exposed chlorella groups. Urinary and serum creatinine, and creatinine clearance were not changed in experimental animals. In addition, metallothionein (MT) synthesis in tissues was increased by Cd administration. The Cd-exposed chlorella groups indicated lower MT concentration compared to the Cd-exposed groups. Moreover, glomerular filtration rate (GFR) was not changed by dietary chlorella and Cd administration. According to the results above, this study could suggest that Cd toxicity can be alleviated by increasing Cd excretion through feces. Therefore, when exposed to Cd, chlorella is an appropriate source which counteracts heavy metal poisoning, to decrease the damage of tissues by decreasing cadmium absorption.
本研究旨在探讨绿藻对镉（Cd）毒性的影响。将 60 只雄性 Sprague-Dawley 大鼠（14 周龄）分为 6 组。给予氯化镉 0 或 325mg（Cd：0，160ppm），绿藻粉 0、3 和 5%。镉在暴露于镉的各组血液和组织（肝、肾和小肠）中积累，而暴露于镉的绿藻组中镉的积累减少。暴露于镉的绿藻组粪便和尿液中的镉排泄量显著增加。因此，镉在暴露于绿藻的组中的保留率和吸收率降低。实验动物的尿和血清肌酐及肌酐清除率没有变化。此外，组织中金属硫蛋白（MT）的合成增加。与暴露于镉的组相比，暴露于镉的绿藻组的 MT 浓度较低。此外，饮食绿藻和镉给药对肾小球滤过率（GFR）没有影响。根据上述结果，本研究表明，通过增加粪便中镉的排泄可以减轻镉毒性。因此，当暴露于镉时，绿藻是一种合适的来源，可以通过减少镉吸收来减轻组织损伤。
