Department of Nutritional Science and Food Management, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-gu, Seoul 120-750, Korea.
Nutr Res Pract. 2009 Spring;3(1):43-8. doi: 10.4162/nrp.2009.3.1.43. Epub 2009 Mar 31.
We investigated the nutritional state of B vitamins and the neuropsychological functions in 25 subjects, aged 63.1 +/- 6.3 years, residing in rural areas of Korea. Nutritional states of thiamin, riboflavin, and pyridoxine were assessed enzymatically in the erythrocytes, and folate concentrations were measured microbiologically in the plasma and erythrocytes. A battery of composite neuropsychological test was administered to the subjects. Plasma folate was correlated with the total intelligence score (p=0.049). Folate levels in the erythrocytes were correlated with the performance intelligence scores such as block design (p=0.017) and picture arrangement (p=0.016). The red cell folate was correlated with memory scores such as general memory (p=0.009) and delayed recall (p=0.000). Although it did not reach statistical significance, verbal memory (p=0.053) was highly correlated with the red cell folate. The red cell folate was also correlated positively with the percent of conceptual level response number score (p=0.029), and negatively with the grooved pegboard test score for the non-dominant hand (p=0.010). Fine motor coordination was also influenced by folate nutrition, as finger tapping scores in both hands were significantly correlated with red cell folate (dominant hand; p=0.026, non-dominant hand; p=0.004). Other B vitamins such as thiamin, riboflavin, and vitamin B(6) were not as strongly correlated with neuropsychological function test scores as folate was. These results suggest that folate nutrition influences neuropsychological function test scores significantly in humans. Further studies are needed to explore the relationship between folate or other vitamin B nutrition and neuropsychological functions and the implications thereof.
我们调查了 25 名年龄为 63.1 ± 6.3 岁、居住在韩国农村地区的研究对象的 B 族维生素营养状况和神经心理学功能。采用酶法测定红细胞中硫胺素、核黄素和吡哆醇的营养状况，用微生物法测定血浆和红细胞中的叶酸浓度。对研究对象进行了一系列复合神经心理学测试。血浆叶酸与总智商评分呈正相关（p=0.049）。红细胞叶酸与执行智力评分呈正相关，如积木设计（p=0.017）和图片排列（p=0.016）。红细胞叶酸与记忆评分呈正相关，如一般记忆（p=0.009）和延迟回忆（p=0.000）。虽然未达到统计学意义，但言语记忆（p=0.053）与红细胞叶酸高度相关。红细胞叶酸与概念水平反应数的百分比评分呈正相关（p=0.029），与非优势手的凹槽钉板测试评分呈负相关（p=0.010）。精细运动协调也受到叶酸营养的影响，因为双手的手指敲击评分与红细胞叶酸呈显著相关（优势手；p=0.026，非优势手；p=0.004）。其他 B 族维生素，如硫胺素、核黄素和维生素 B(6)，与神经心理学功能测试评分的相关性不如叶酸强。这些结果表明，叶酸营养对人类神经心理学功能测试评分有显著影响。需要进一步研究来探讨叶酸或其他维生素 B 营养与神经心理学功能及其影响之间的关系。
