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用阿糖腺苷和单磷酸阿糖腺苷局部治疗后小鼠感觉神经节中的潜伏性单纯疱疹病毒感染

Latent herpes simplex virus infections in sensory ganglia of mice after topical treatment with adenine arabinoside and adenine arabinoside monophosphate.

作者信息

Klein R J, Friedman-Kien A E

出版信息

Antimicrob Agents Chemother. 1977 Nov;12(5):577-81. doi: 10.1128/AAC.12.5.577.

Abstract

Adenine arabinoside (Ara-A) and Ara-A monosphosphate (Ara-AMP) ointments were able to prevent the fatal outcome of herpes simplex virus (HSV)-induced skin infection of the lumbosacral area in hairless mice. Ara-A and Ara-AMP had no irritating effect on the skin, but in a number of animals a protracted healing time of the skin lesions after the treatment was observed. The compounds conferred only a partial protection against the establishment of latent HSV infection in the spinal root ganglia of the treated animals. The immune response, as judged from levels of HSV-specific neutralizing serum antibody titers, was not impaired by the antiviral treatment.

摘要

阿糖腺苷(Ara - A)和单磷酸阿糖腺苷(Ara - AMP)软膏能够预防单纯疱疹病毒(HSV)诱发的无毛小鼠腰骶部皮肤感染的致命后果。Ara - A和Ara - AMP对皮肤无刺激作用,但在一些动物中,观察到治疗后皮肤损伤的愈合时间延长。这些化合物仅对治疗动物脊髓神经根神经节中潜伏性HSV感染的建立提供部分保护。从HSV特异性中和血清抗体滴度水平判断,抗病毒治疗并未损害免疫反应。

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Effects of adenine arabinoside on cellular immune mechanisms in humans.
Antimicrob Agents Chemother. 1975 Feb;7(2):203-7. doi: 10.1128/AAC.7.2.203.
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Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia.
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