用阿糖腺苷和单磷酸阿糖腺苷局部治疗后小鼠感觉神经节中的潜伏性单纯疱疹病毒感染
Latent herpes simplex virus infections in sensory ganglia of mice after topical treatment with adenine arabinoside and adenine arabinoside monophosphate.
作者信息
Klein R J, Friedman-Kien A E
出版信息
Antimicrob Agents Chemother. 1977 Nov;12(5):577-81. doi: 10.1128/AAC.12.5.577.
Abstract
Adenine arabinoside (Ara-A) and Ara-A monosphosphate (Ara-AMP) ointments were able to prevent the fatal outcome of herpes simplex virus (HSV)-induced skin infection of the lumbosacral area in hairless mice. Ara-A and Ara-AMP had no irritating effect on the skin, but in a number of animals a protracted healing time of the skin lesions after the treatment was observed. The compounds conferred only a partial protection against the establishment of latent HSV infection in the spinal root ganglia of the treated animals. The immune response, as judged from levels of HSV-specific neutralizing serum antibody titers, was not impaired by the antiviral treatment.
摘要
阿糖腺苷（Ara - A）和单磷酸阿糖腺苷（Ara - AMP）软膏能够预防单纯疱疹病毒（HSV）诱发的无毛小鼠腰骶部皮肤感染的致命后果。Ara - A和Ara - AMP对皮肤无刺激作用，但在一些动物中，观察到治疗后皮肤损伤的愈合时间延长。这些化合物仅对治疗动物脊髓神经根神经节中潜伏性HSV感染的建立提供部分保护。从HSV特异性中和血清抗体滴度水平判断，抗病毒治疗并未损害免疫反应。
相似文献
1
Latent herpes simplex virus infections in sensory ganglia of mice after topical treatment with adenine arabinoside and adenine arabinoside monophosphate.用阿糖腺苷和单磷酸阿糖腺苷局部治疗后小鼠感觉神经节中的潜伏性单纯疱疹病毒感染
Antimicrob Agents Chemother. 1977 Nov;12(5):577-81. doi: 10.1128/AAC.12.5.577.
2
Orofacial herpes simplex virus infection in hairless mice: latent virus in trigeminal ganglia after topical antiviral treatment.无毛小鼠的口腔面部单纯疱疹病毒感染：局部抗病毒治疗后三叉神经节中的潜伏病毒
Infect Immun. 1978 Apr;20(1):130-5. doi: 10.1128/iai.20.1.130-135.1978.
3
Antiviral activity in the rabbit cornea of adenine arabinoside, Ara-A 5' monophosphate, and hypoxanthine arabinoside; and interactions with adenosine deaminase inhibitor.阿糖腺苷、阿糖腺苷5′单磷酸酯及阿糖次黄嘌呤在兔角膜中的抗病毒活性；以及与腺苷脱氨酶抑制剂的相互作用。
J Gen Virol. 1977 Jul;36(1):199-202. doi: 10.1099/0022-1317-36-1-199.
4
Antiherpesvirus activity in human sera and urines after administration of adenine arabinoside: in vitro and in vivo synergy of adenine arabinoside and arabinosylhypoxanthine in combination.阿糖腺苷给药后人体血清和尿液中的抗疱疹病毒活性：阿糖腺苷与阿糖次黄嘌呤联合应用的体内外协同作用。
J Clin Invest. 1978 Dec;62(6):1142-53. doi: 10.1172/JCI109233.
5
Anti-herpesvirus activity of adenine arabinoside analogues in tissue culture and a genital infection of mice and guinea pigs.阿糖腺苷类似物在组织培养以及小鼠和豚鼠生殖器感染中的抗疱疹病毒活性
Antiviral Res. 1982 May;2(1-2):27-39. doi: 10.1016/0166-3542(82)90024-9.
6
Alteration of mortality and pathogenesis of three experimental Herpesvirus hominis infections of mice with adenine arabinoside 5'-monophosphate, adenine arabinoside, and phosphonoacetic acid.用阿糖腺苷5'-单磷酸、阿糖腺苷和膦甲酸对小鼠的三种人疱疹病毒实验性感染的死亡率和发病机制的改变
Antimicrob Agents Chemother. 1978 Jan;13(1):53-60. doi: 10.1128/AAC.13.1.53.
7
8
Iontophoretic application of adenine arabinoside monophosphate to herpes simplex virus type 1-infected hairless mouse skin.将单磷酸阿糖腺苷通过离子导入法应用于1型单纯疱疹病毒感染的无毛小鼠皮肤。
Antimicrob Agents Chemother. 1978 Oct;14(4):605-8. doi: 10.1128/AAC.14.4.605.
9
Latent infections of sensory ganglia as influenced by phosphonoformate treatment of herpes simplex virus-induced skin infections in hairless mice.膦甲酸处理无毛小鼠单纯疱疹病毒诱导的皮肤感染对感觉神经节潜伏感染的影响。
Antimicrob Agents Chemother. 1979 Sep;16(3):266-70. doi: 10.1128/AAC.16.3.266.
10
Immune response and latent infection after topical treatment of herpes simplex virus infection in hairless mice.无毛小鼠单纯疱疹病毒感染局部治疗后的免疫反应和潜伏感染
Infect Immun. 1977 Jun;16(3):842-8. doi: 10.1128/iai.16.3.842-848.1977.
引用本文的文献
1
Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.用（E）-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物对无毛小鼠皮肤单纯疱疹病毒感染进行局部治疗。
Antimicrob Agents Chemother. 1984 Aug;26(2):155-9. doi: 10.1128/AAC.26.2.155.
2
Persistent reactivable latent herpes simplex virus infection in trigeminal ganglia of mice treated with antiviral drugs.抗病毒药物治疗的小鼠三叉神经节中持续性可再激活的潜伏单纯疱疹病毒感染
Arch Virol. 1981;69(1):43-8. doi: 10.1007/BF01315264.
3
The pathogenesis of acute, latent and recurrent herpes simplex virus infections.单纯疱疹病毒急性、潜伏和复发性感染的发病机制。
Arch Virol. 1982;72(3):143-68. doi: 10.1007/BF01348961.
4
Effects of topical applications of phosphonoacetate on colonization of mouse trigeminal ganglia with herpes simplex virus type 1.膦酰乙酸局部应用对1型单纯疱疹病毒在小鼠三叉神经节中定植的影响。
Antimicrob Agents Chemother. 1984 Jul;26(1):65-8. doi: 10.1128/AAC.26.1.65.
5
Rapid and accurate viral diagnosis.快速准确的病毒诊断。
Pharmacol Ther. 1989;40(2):287-328. doi: 10.1016/0163-7258(89)90098-3.
6
Novel animal model for evaluating topical efficacy of antiviral agents: flux versus efficacy correlations in the acyclovir treatment of cutaneous herpes simplex virus type 1 (HSV-1) infections in hairless mice.评估抗病毒药物局部疗效的新型动物模型：阿昔洛韦治疗无毛小鼠皮肤单纯疱疹病毒1型（HSV-1）感染时的通量与疗效相关性
Pharm Res. 1992 Aug;9(8):979-89. doi: 10.1023/a:1015838007864.
7
Latent infections of sensory ganglia as influenced by phosphonoformate treatment of herpes simplex virus-induced skin infections in hairless mice.膦甲酸处理无毛小鼠单纯疱疹病毒诱导的皮肤感染对感觉神经节潜伏感染的影响。
Antimicrob Agents Chemother. 1979 Sep;16(3):266-70. doi: 10.1128/AAC.16.3.266.
8
Latent herpes simplex virus infections in sensory ganglia of hairless mice prevented by acycloguanosine.无环鸟苷可预防无毛小鼠感觉神经节中的潜伏性单纯疱疹病毒感染。
Antimicrob Agents Chemother. 1979 May;15(5):723-9. doi: 10.1128/AAC.15.5.723.
9
Orofacial herpes simplex virus infection in hairless mice: latent virus in trigeminal ganglia after topical antiviral treatment.无毛小鼠的口腔面部单纯疱疹病毒感染：局部抗病毒治疗后三叉神经节中的潜伏病毒
Infect Immun. 1978 Apr;20(1):130-5. doi: 10.1128/iai.20.1.130-135.1978.
本文引用的文献
1
Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection.阿糖腺苷对实验性耐碘苷单纯疱疹病毒感染的作用
Invest Ophthalmol. 1974 Apr;13(4):302-4.
2
Effects of adenine arabinoside on cellular immune mechanisms in humans.阿糖腺苷对人体细胞免疫机制的影响。
Antimicrob Agents Chemother. 1975 Feb;7(2):203-7. doi: 10.1128/AAC.7.2.203.
3
Immune response and latent infection after topical treatment of herpes simplex virus infection in hairless mice.无毛小鼠单纯疱疹病毒感染局部治疗后的免疫反应和潜伏感染
Infect Immun. 1977 Jun;16(3):842-8. doi: 10.1128/iai.16.3.842-848.1977.
4
Cellular immune responses to herpesviruses during treatment with adenine arabinoside.在用阿糖腺苷治疗期间对疱疹病毒的细胞免疫反应。
J Infect Dis. 1977 Apr;135(4):593-9. doi: 10.1093/infdis/135.4.593.
5
Genital Herpesvirus homonis infection in mice. II. Treatment with phosphonoacetic acid, adenine arabinoside, and adenine arabinoside 5'-monophosphate.小鼠人单纯疱疹病毒感染。II. 膦甲酸、阿糖腺苷及阿糖腺苷5'-单磷酸的治疗
J Infect Dis. 1977 Apr;135(4):557-67. doi: 10.1093/infdis/135.4.557.
6
Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia.膦甲酸钠对感觉神经节单纯疱疹病毒感染的疗效。
Infect Immun. 1976 May;13(5):1519-21. doi: 10.1128/iai.13.5.1519-1521.1976.
7
Prospective double-blind evaluation of topical adenine arabinoside in male herpes progenitalis.阿糖腺苷局部用药治疗男性生殖器疱疹的前瞻性双盲评估
Antimicrob Agents Chemother. 1975 Dec;8(6):693-7. doi: 10.1128/AAC.8.6.693.
8
Isolation of herpes simplex virus clones and drug resistant mutants in microcultures.在微量培养中分离单纯疱疹病毒克隆和耐药突变体。
Arch Virol. 1975;49(1):73-80. doi: 10.1007/BF02175598.
9
Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice.无毛小鼠中耐膦酰乙酸的单纯疱疹病毒感染
Antimicrob Agents Chemother. 1975 Mar;7(3):289-93. doi: 10.1128/AAC.7.3.289.
Zotero 插件