Klein R J, Friedman-Kien A E
Antimicrob Agents Chemother. 1977 Nov;12(5):577-81. doi: 10.1128/AAC.12.5.577.
Adenine arabinoside (Ara-A) and Ara-A monosphosphate (Ara-AMP) ointments were able to prevent the fatal outcome of herpes simplex virus (HSV)-induced skin infection of the lumbosacral area in hairless mice. Ara-A and Ara-AMP had no irritating effect on the skin, but in a number of animals a protracted healing time of the skin lesions after the treatment was observed. The compounds conferred only a partial protection against the establishment of latent HSV infection in the spinal root ganglia of the treated animals. The immune response, as judged from levels of HSV-specific neutralizing serum antibody titers, was not impaired by the antiviral treatment.
阿糖腺苷(Ara - A)和单磷酸阿糖腺苷(Ara - AMP)软膏能够预防单纯疱疹病毒(HSV)诱发的无毛小鼠腰骶部皮肤感染的致命后果。Ara - A和Ara - AMP对皮肤无刺激作用,但在一些动物中,观察到治疗后皮肤损伤的愈合时间延长。这些化合物仅对治疗动物脊髓神经根神经节中潜伏性HSV感染的建立提供部分保护。从HSV特异性中和血清抗体滴度水平判断,抗病毒治疗并未损害免疫反应。