膦酰乙酸局部应用对1型单纯疱疹病毒在小鼠三叉神经节中定植的影响。
Effects of topical applications of phosphonoacetate on colonization of mouse trigeminal ganglia with herpes simplex virus type 1.
作者信息
Klein R J, Friedman-Kien A E, Kaley L, Brady E
出版信息
Antimicrob Agents Chemother. 1984 Jul;26(1):65-8. doi: 10.1128/AAC.26.1.65.
The effects of topical application of phosphonoacetic acid on the colonization of mouse trigeminal ganglia by herpes simplex virus type 1 were examined. The results showed that the extent of colonization of ganglia by virus is related to the time elapsed between virus inoculation and application of this agent. In most cases, treatment started up to 12 h after inoculation prevented invasion of ganglia by virus. When started up to 24 h after inoculation, treatment reduced and stabilized the amount of virus detectable in trigeminal ganglia during the acute phase of the ganglionic infection. Treatments started 24 h after virus inoculation had little influence on total virus accumulations in trigeminal ganglia. The data also indicate that virus titers in specimens of inoculated and treated skin sites are less affected by topical phosphonoacetic acid treatment than virus titers in ganglia. The experiments may represent a model system for testing effects of other antiviral compounds on colonization of ganglia by virus and may provide some clues regarding the pathogenic mechanism of herpes simplex virus infections.
研究了局部应用膦甲酸钠对1型单纯疱疹病毒在小鼠三叉神经节中定植的影响。结果表明，病毒在神经节中的定植程度与接种病毒和应用该药物之间的时间间隔有关。在大多数情况下，接种后12小时内开始治疗可防止病毒侵入神经节。接种后24小时内开始治疗，可在神经节感染急性期减少并稳定三叉神经节中可检测到的病毒量。接种病毒24小时后开始治疗对三叉神经节中病毒的总积累影响很小。数据还表明，与神经节中的病毒滴度相比，局部膦甲酸钠治疗对接种和治疗皮肤部位标本中的病毒滴度影响较小。这些实验可能代表了一个测试其他抗病毒化合物对病毒在神经节中定植影响的模型系统，并可能为单纯疱疹病毒感染的致病机制提供一些线索。
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