乳腺癌患者血清和唾液中CA125水平的相关性
Correlation of serum and salivary CA125 levels in patients with breast cancer.
作者信息
Agha-Hosseini Farzaneh, Mirzaii-Dizgah Iraj, Rahimi Asieh, Seilanian-Toosi Mehdi
机构信息
Department of Oral Medicine, Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
J Contemp Dent Pract. 2009 Nov 1;10(6):E001-8.
AIM
The aim of this study was to examine the relationship between serum and saliva levels of cancer antigen (CA) 125 and compare them among healthy women and patients with treated and untreated breast cancer.
METHODS AND MATERIALS
CA125 levels were assayed in serum and unstimulated whole saliva of 25 normal healthy women, 24 patients with untreated breast cancer, and 23 patients with treated breast cancer using enzyme immunoassay (EIA) kits.
RESULTS
The mean saliva and serum CA125 levels were significantly higher in untreated cancer women compared to healthy and treated groups. The serum and saliva CA125 levels showed a significant modest positive correlation (r=0.38; p=0.01).
CONCLUSION
CA125 level in saliva is higher than in serum with a modest positive correlation between each other.
CLINICAL SIGNIFICANCE
Serum and salivary CA125 levels were significantly higher in women with untreated breast cancer than healthy women and women who were treated for breast cancer.
目的
本研究旨在探讨癌抗原（CA）125血清和唾液水平之间的关系，并在健康女性、接受治疗和未接受治疗的乳腺癌患者之间进行比较。
方法和材料
使用酶免疫分析（EIA）试剂盒，对25名正常健康女性、24名未接受治疗的乳腺癌患者和23名接受治疗的乳腺癌患者的血清和未刺激的全唾液中的CA125水平进行检测。
结果
与健康组和治疗组相比，未接受治疗的癌症女性的唾液和血清CA125平均水平显著更高。血清和唾液CA125水平呈显著的中度正相关（r=0.38；p=0.01）。
结论
唾液中的CA125水平高于血清，且两者之间存在中度正相关。
临床意义
未接受治疗的乳腺癌女性的血清和唾液CA125水平显著高于健康女性和接受乳腺癌治疗的女性。
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