Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
J Peripher Nerv Syst. 2009 Dec;14(4):310-5. doi: 10.1111/j.1529-8027.2009.00243.x.
We determined the frequency of recurrent Guillain-Barré syndrome (GBS), whether vaccinations led to recurrences of GBS or an increase of disability in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and we assessed the prevalence of pain, fatigue and the impact on quality of life after GBS and CIDP. Additionally, we assessed the presence of common auto-immune disorders. Four hundred and sixty-one members of the Dutch society of neuromuscular disorders received a questionnaire. Two hundred and forty-five GBS and seventy-six CIDP patients were included (response rate 70%). Nine patients had a confirmed recurrent GBS, and two patients had experienced both GBS and CIDP. Common auto-immune diseases were reported in 9% of GBS and 5% of CIDP patients. None of the 106 GBS patients who received a flu vaccination (range 1-37 times, total 775 vaccinations) reported a recurrence thereafter. Five out of twenty-four CIDP patients who received a flu vaccination (range 1-17 times) reported an increase in symptoms. Pain or severe fatigue was reported in about 70% of patients after the diagnosis of GBS (median 10 years) or after onset of CIDP (median 6 years), and quality of life was significantly reduced. Flu vaccinations seem relatively safe. GBS and CIDP patients often experience pain, fatigue and a reduced quality of life for many years after the diagnosis.
我们确定了复发性吉兰-巴雷综合征（GBS）的频率，是否接种疫苗会导致 GBS 复发或慢性炎症性脱髓鞘性多发性神经病（CIDP）的残疾加重，我们评估了 GBS 和 CIDP 后的疼痛、疲劳和对生活质量的影响的患病率。此外，我们还评估了常见自身免疫性疾病的存在。荷兰神经肌肉疾病协会的 461 名成员收到了一份问卷。245 名 GBS 和 76 名 CIDP 患者被纳入（应答率为 70%）。9 名患者确诊为复发性 GBS，2 名患者经历过 GBS 和 CIDP。GBS 患者中有 9%和 CIDP 患者中有 5%报告存在常见自身免疫性疾病。在接受流感疫苗接种的 106 名 GBS 患者中（接种范围 1-37 次，总接种 775 次），无人报告此后复发。24 名接受流感疫苗接种的 CIDP 患者中有 5 名（接种范围 1-17 次）报告症状加重。诊断为 GBS（中位数 10 年）或 CIDP 后（中位数 6 年）后，约 70%的患者报告出现疼痛或严重疲劳，生活质量明显下降。流感疫苗接种似乎相对安全。GBS 和 CIDP 患者在诊断后多年经常经历疼痛、疲劳和生活质量下降。
