Ufuk University, Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey.
Reprod Biomed Online. 2009 Nov;19(5):721-6. doi: 10.1016/j.rbmo.2009.06.005.
Polycystic ovary syndrome (PCOS) shares some or most components of metabolic cardiovascular syndrome, manifested by abdominal obesity, insulin resistance, dyslipidaemia and atherosclerosis. It has been previously demonstrated that folate and vitamin B(12) treatment improved insulin resistance in patients with metabolic syndrome. This study first investigated whether PCOS patients have lower or higher vitamin B(12), folate and homocysteine concentrations when compared with healthy, age and body mass index matched controls, and, then examined associations between vitamin B(12), folate, homocysteine and insulin resistance and obesity in PCOS patients. Homocysteine concentrations and homeostasis model assessment index were higher, whereas concentrations of vitamin B(12) were lower in PCOS patients with insulin resistance compared with those without insulin resistance. Serum vitamin B(12) concentrations were significantly lower in obese PCOS women in comparison with obese control women (P < 0.05). Fasting insulin, insulin resistance and homocysteine are independent determinants of serum vitamin B(12) concentrations in PCOS patients. Insulin resistance, obesity, and elevated homocysteine were associated with lower serum vitamin B(12) concentrations in PCOS patients.
多囊卵巢综合征（PCOS）与代谢性心血管综合征共享一些或大多数成分，表现为腹部肥胖、胰岛素抵抗、血脂异常和动脉粥样硬化。先前已经证明，叶酸和维生素 B(12)治疗可以改善代谢综合征患者的胰岛素抵抗。本研究首先调查与年龄和体重指数匹配的健康对照组相比，PCOS 患者的维生素 B(12)、叶酸和同型半胱氨酸浓度是否更低或更高，然后检查 PCOS 患者中维生素 B(12)、叶酸、同型半胱氨酸与胰岛素抵抗和肥胖之间的关系。胰岛素抵抗的 PCOS 患者的同型半胱氨酸浓度和稳态模型评估指数较高，而维生素 B(12)浓度较低。与肥胖对照组女性相比，肥胖的 PCOS 女性血清维生素 B(12)浓度显著降低（P<0.05）。空腹胰岛素、胰岛素抵抗和同型半胱氨酸是 PCOS 患者血清维生素 B(12)浓度的独立决定因素。胰岛素抵抗、肥胖和同型半胱氨酸升高与 PCOS 患者的血清维生素 B(12)浓度降低有关。
