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[多囊卵巢综合征:新的且有前景的治疗方法]

[Polycystic ovary syndrome: new and promising treatment methods].

作者信息

Gasieva D M, Sheremetyeva E V, Kalashnikova M F, Dzgoeva F Kh, Alborova E T

机构信息

Endocrinology Research Centre.

N.V. Sklifosovskiy Institute of Clinical Medicine.

出版信息

Probl Endokrinol (Mosk). 2024 Sep 16;70(4):103-113. doi: 10.14341/probl13400.

Abstract

Polycystic Ovary Syndrome (PCOS) - is a polygenic endocrine disorder caused by genetic, hormonal, and epigenetic factors. The importance of addressing PCOS lies in its prevalence, affecting approximately 10 to 13% of women, as well as the associated health conditions that can have a negative impact on women's lives, including infertility, dermatological manifestations of hyperandrogenism (such as hirsutism and acne), cardiovascular pathologies, metabolic disorders, and psychoemotional disorders. Currently, many theories of the development of this disease have been proposed, and as a consequence of methods of influencing and treating it. According to the clinical recommendations of the Ministry of Health of the Russian Federation, modifying the patient's lifestyle forms the basis of comprehensive therapy. We have analyzed about 60 articles on various dietary approaches to the treatment of PCOS, sourced from PubMed, Nature Reviews, Oxford Academic, Clinical Nutrition, EJOG, ScienceDirect, and MDPI. The Mediterranean diet, the DASH diet, the ketogenic diet and the low-carb diet have proven themselves the best. Also, it's necessary to add vitamin D, E, folic acid, calcium, various pro- and prebiotics to a woman's diet. Currently, the use of inositol and GPP-1 is becoming a promising method of PCOS therapy. According to the results of the analysis, a positive effect of diet therapy on the anthropometric and biochemical parameters was noted. Based on the analysis, a positive effect of diet therapy on anthropometric and biochemical parameters has been observed. It is crucial to consider the individual characteristics of each patient and not rely solely on drug therapy when approaching the treatment of PCOS.

摘要

多囊卵巢综合征(PCOS)——是一种由遗传、激素和表观遗传因素引起的多基因内分泌疾病。解决PCOS问题的重要性在于其普遍性,约10%至13%的女性受其影响,以及相关健康状况会对女性生活产生负面影响,包括不孕、高雄激素血症的皮肤表现(如多毛症和痤疮)、心血管疾病、代谢紊乱和心理情绪障碍。目前,关于这种疾病的发展已经提出了许多理论,以及相应的影响和治疗方法。根据俄罗斯联邦卫生部的临床建议,改变患者的生活方式是综合治疗的基础。我们分析了约60篇关于治疗PCOS的各种饮食方法的文章,这些文章来自PubMed、《自然综述》、牛津学术、《临床营养》、《欧洲妇产科与生殖生物学杂志》、《科学Direct》和MDPI。地中海饮食、得舒饮食、生酮饮食和低碳水化合物饮食已被证明是最佳的。此外,有必要在女性饮食中添加维生素D、E、叶酸、钙、各种益生元和益生菌。目前,使用肌醇和GPP - 1正成为一种有前景的PCOS治疗方法。根据分析结果,注意到饮食疗法对人体测量和生化参数有积极影响。基于该分析,已观察到饮食疗法对人体测量和生化参数有积极影响。在治疗PCOS时,考虑每个患者的个体特征并不仅仅依赖药物治疗至关重要。

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