Internal Medicine Department, Botucatu Medical School, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.
Chemistry and Biochemistry Department, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil.
PLoS One. 2022 Mar 4;17(3):e0264854. doi: 10.1371/journal.pone.0264854. eCollection 2022.
Myocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Açai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of açai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% açai pulp (SA2, n = 12) and fed standard chow with 5% açai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% açai pulp (IA2, n = 12), and fed standard chow with 5% açai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Açai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P<0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P<0.001; dose-dependent effect). In conclusion, açai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of açai pulp supplementation have dose-dependent effects on cardiac remodeling.
心肌梗死在全球范围内具有较高的死亡率。因此，临床干预心肌梗死后的心脏重构至关重要。阿萨伊浆果果浆是一种天然产物，因其具有抗氧化/抗炎特性而被认为是一种功能性食品。本研究旨在分析阿萨伊浆果果浆补充对心肌梗死后大鼠心脏重构的影响。手术后 7 天，雄性 Wistar 大鼠被分为六组：假手术组给予标准饲料（SA0，n=14）、给予标准饲料加 2%阿萨伊浆果果浆（SA2，n=12）和给予标准饲料加 5%阿萨伊浆果果浆（SA5，n=14）、心肌梗死组给予标准饲料（IA0，n=12）、给予标准饲料加 2%阿萨伊浆果果浆（IA2，n=12）和给予标准饲料加 5%阿萨伊浆果果浆（IA5，n=12）。补充 3 个月后，进行超声心动图检查和安乐死。心肌梗死后，阿萨伊浆果果浆补充改善了能量代谢，减弱了氧化应激（丙二醛浓度降低，P=0.023；呈剂量依赖性），调节了炎症过程（白细胞介素-10 浓度降低，P<0.001；呈剂量依赖性），并减少了胶原蛋白沉积（间质胶原分数的百分比降低，P<0.001；呈剂量依赖性）。总之，阿萨伊浆果果浆补充减轻了大鼠心肌梗死后的心脏重构。此外，不同剂量的阿萨伊浆果果浆补充对心脏重构具有剂量依赖性作用。
