Dept. of Neurology, Philipps-University Marburg, Rudolf-Bultmannstr. 8, 35039 Marburg, Germany.
Parkinsonism Relat Disord. 2010 May;16(4):243-8. doi: 10.1016/j.parkreldis.2009.11.012. Epub 2009 Dec 21.
Parkinson's disease (PD) is a chronic neurodegenerative disorder that has a major impact on health and longevity in Eastern countries. Studies investigating health-related quality of life (HRQoL) in Eastern European and Asian countries are scarce. The objective of this cross-sectional survey was to assess HRQoL in Russian patients with PD and identify its social and clinical determinants. The study included 100 outpatients with idiopathic PD and 100 controls. Patients were consecutively recruited from the neurological department of the Russian Medical State University in Moscow between October 2004 and December 2005. Regional healthy controls were matched for age and sex. The evaluation of HRQoL was performed using the EuroQol instrument (EQ-5D and EQ VAS). Disease severity was assessed using the Unified Parkinson's Disease Rating Scale (UPDRS). Multivariate regression analyses were used to identify independent determinants of HRQoL. HRQoL was more notably decreased in PD patients than in controls (98% versus 74% of individuals with moderate or severe problems in at least one dimension of the EQ-5D (p < 0.001), respectively). As compared to patients, the controls reported a higher mean EQ VAS score (74.0 +/- 16.0 versus 47.7 +/- 16.7, p < 0.001). Social and clinical determinants of HRQoL were age, disease severity, dystonia, depression, dementia and social support. While the HRQoL of patients with PD in Western countries is predominately affected by clinical parameters, social factors play an important role in Eastern countries. Our data should be considered in the development of national healthcare programs that seek to provide better social services support for patients with PD.
帕金森病（PD）是一种慢性神经退行性疾病，对东方国家的健康和寿命有重大影响。研究东欧和亚洲国家与健康相关的生活质量（HRQoL）的研究很少。本横断面调查的目的是评估俄罗斯 PD 患者的 HRQoL，并确定其社会和临床决定因素。该研究纳入了 2004 年 10 月至 2005 年 12 月期间在莫斯科俄罗斯国立医科大学神经科连续招募的 100 名特发性 PD 门诊患者和 100 名对照者。按年龄和性别与患者匹配区域性健康对照者。使用 EuroQol 工具（EQ-5D 和 EQ VAS）评估 HRQoL。使用统一帕金森病评定量表（UPDRS）评估疾病严重程度。使用多元回归分析确定 HRQoL 的独立决定因素。PD 患者的 HRQoL 明显低于对照组（至少在 EQ-5D 的一个维度中有中度或重度问题的个体，PD 患者为 98%，对照组为 74%，p<0.001）。与患者相比，对照组报告的 EQ VAS 评分平均值更高（74.0+/-16.0 对 47.7+/-16.7，p<0.001）。HRQoL 的社会和临床决定因素包括年龄、疾病严重程度、肌张力障碍、抑郁、痴呆和社会支持。虽然西方 PD 患者的 HRQoL 主要受临床参数的影响，但在东方国家，社会因素起着重要作用。在制定旨在为 PD 患者提供更好的社会服务支持的国家卫生保健计划时，应考虑到我们的数据。
