Cano-de la Cuerda Roberto, Vela-Desojo Lydia, Miangolarra-Page Juan C, Macías-Macías Yolanda, Muñoz-Hellin Elena
Departamento de Fisioterapia, Terapia Ocupacional, Medicina Física y Rehabilitación, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos (URJC), Alcorcón, Madrid, España.
Medicina (B Aires). 2010;70(6):503-7.
Parkinson's disease is a disabling and progressive neurological condition characterized by multiple motor and non motor symptoms that contribute to deterioration in quality of life. The diversity of symptoms associated with the disease and its management affect the patients on their physical, social and mental quality of life. The aim of this study was to identify key dimensions of health related quality of life (HRQOL) in a population affected with Parkinson's disease with a degree of mild-moderate impairment. Thirty six patients with Parkinson were recruited. The Hoehn and Yarh scale, the Unified Parkinson's Disease Rate Scale, the scale of activities of daily life and Schwab & England Get Up & Go Test were applied. HRQOL was assessed with the EuroQol-5D and the specific questionnaire Parkinson's Disease Questionnaire-39 items. The dimensions of the PDQ-39, except the PDQ-39 Pain domain and the EuroQol-5D correlated significantly with the severity of the disease. HRQOL was correlated with the functional status of patients. Only the PDQ-39 pain domain correlated with the risk of falls. Our results suggest that the HRQOL of patients with PD, in a state of mild-moderate impairment, is strongly influenced by disease severity and functional status.
帕金森病是一种致残性的进行性神经疾病，其特征是多种运动和非运动症状，这些症状会导致生活质量下降。与该疾病及其管理相关的症状多样性会影响患者的身体、社会和心理生活质量。本研究的目的是确定在轻度至中度受损程度的帕金森病患者群体中与健康相关生活质量（HRQOL）的关键维度。招募了36名帕金森病患者。应用了霍恩和亚尔分级量表、统一帕金森病评定量表、日常生活活动量表以及施瓦布和英格兰起身行走测试。使用欧洲五维健康量表（EuroQol-5D）和特定问卷帕金森病问卷-39项来评估HRQOL。帕金森病问卷-39项（PDQ-39）的维度，除了PDQ-39疼痛领域外，以及欧洲五维健康量表均与疾病严重程度显著相关。HRQOL与患者的功能状态相关。只有PDQ-39疼痛领域与跌倒风险相关。我们的结果表明，处于轻度至中度受损状态的帕金森病患者的HRQOL受到疾病严重程度和功能状态的强烈影响。
