Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, MA 02111, USA.
Curr Opin Microbiol. 2010 Feb;13(1):18-23. doi: 10.1016/j.mib.2009.11.004. Epub 2009 Dec 21.
The ubiquity of small RNAs (sRNAs) in bacteria is now well established. These transcripts are the members of regulatory circuits involved in diverse processes ranging from stress adaptation to virulence to metabolism. Recent large-scale searches suggest that there exist many times more sRNAs than previously predicted even in the best studied bacterial transcriptomes. On the basis of these and other recent findings of regulatory sRNAs that do not function in a 'classical' manner, we propose that the working definition of sRNAs be broadened.
小 RNA（sRNA）在细菌中的普遍性现在已经得到充分证实。这些转录物是参与各种过程的调节回路的成员，这些过程从应激适应到毒力到代谢。最近的大规模搜索表明，即使在研究最好的细菌转录组中，sRNA 的数量也比以前预测的要多得多。基于这些以及其他最近发现的不以“经典”方式发挥作用的调节 sRNA 的发现，我们建议扩大 sRNA 的工作定义。
