载脂蛋白 D：在衰老和与年龄相关疾病中的作用概述。
Apolipoprotein D: an overview of its role in aging and age-related diseases.
机构信息
Division of Biology, California Institute of Technology, Pasadena, CA, USA.
出版信息
Cell Cycle. 2010 Jan 15;9(2):269-73. doi: 10.4161/cc.9.2.10433. Epub 2010 Jan 26.
Abstract
“” —Seymour Benzer, reflecting on the observation that ApoD mRNA levels increase 500-fold following neuronal crush injury. Seymour Benzer’s curiosity was legendary and seemingly limitless. Towards the end of his life, one of the (many) questions that kept him awake at night concerned the emerging role of Apolipoprotein D (ApoD) in aging and neurological disease. In this perspective, we will discuss the clinical and biochemical data on ApoD, and the input from the recent genetic studies in model systems, including those from the Benzer lab.
摘要
——西摩·本泽尔（Seymour Benzer），在观察到神经元挤压损伤后 ApoD mRNA 水平增加 500 倍时的感想。西摩·本泽尔（Seymour Benzer）的好奇心是出了名的，而且似乎是无穷无尽的。在他生命的最后阶段，困扰他夜不能寐的（众多）问题之一是载脂蛋白 D（ApoD）在衰老和神经疾病中的新作用。在这篇观点文章中，我们将讨论 ApoD 的临床和生化数据，以及最近来自模型系统的遗传研究的结果，包括本泽尔实验室的研究。
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Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila.人类载脂蛋白D（ApoD）是一种在神经退行性疾病中上调的载脂蛋白，可延长果蝇的寿命并增强其抗应激能力。
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10
Seymour Benzer (1921-2007).
Curr Biol. 2008 Feb 12;18(3):R106-10. doi: 10.1016/j.cub.2007.12.039.
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