共定位神经肽的相互作用：在昼夜节律系统中的功能意义。
Interaction of colocalized neuropeptides: functional significance in the circadian timing system.
作者信息
Albers H E, Liou S Y, Stopa E G, Zoeller R T
机构信息
Department of Biology, Georgia State University, Atlanta 30303.
出版信息
J Neurosci. 1991 Mar;11(3):846-51. doi: 10.1523/JNEUROSCI.11-03-00846.1991.
The suprachiasmatic nucleus (SCN), which appears to act as a circadian clock, contains a subpopulation of local circuit neurons in which vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI), and gastrin releasing peptide (GRP) are colocalized. To determine whether VIP, PHI, and GRP interact within the SCN to produce a signal important for circadian control, the behavioral and cellular effects of coadministration of these neuropeptides were investigated. Coadministration of VIP, PHI, and GRP within the SCN mimicked the phase-delaying effects of light on circadian control following in vivo microinjection and activated SCN single units recorded in vitro. These behavioral and cellular effects of coadministration of VIP, PHI, and GRP were significantly greater than administration of VIP, PHI, or GRP alone or coadministration of any 2 of these peptides. These data illustrate a new mechanism whereby multiple, colocalized neuropeptides interact in a functionally significant manner, and indicate that the interaction of VIP, PHI, and GRP may be involved in the regulation of circadian rhythms by the SCN.
视交叉上核（SCN）似乎起着昼夜节律钟的作用，其中包含一群局部回路神经元，血管活性肠肽（VIP）、肽组氨酸异亮氨酸（PHI）和胃泌素释放肽（GRP）在这些神经元中共定位。为了确定VIP、PHI和GRP是否在SCN内相互作用以产生对昼夜节律控制至关重要的信号，研究了共同施用这些神经肽的行为和细胞效应。在SCN内共同施用VIP、PHI和GRP模拟了体内微量注射后光对昼夜节律控制的相位延迟效应，并激活了体外记录的SCN单个神经元。共同施用VIP、PHI和GRP的这些行为和细胞效应明显大于单独施用VIP、PHI或GRP或共同施用其中任何两种肽。这些数据说明了一种新机制，即多种共定位的神经肽以功能上有意义的方式相互作用，并表明VIP、PHI和GRP的相互作用可能参与SCN对昼夜节律的调节。
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