Department of Chemistry, Tufts University, Medford, MA 02116, USA.
Chem Soc Rev. 2010 Jan;39(1):38-50. doi: 10.1039/b809339n. Epub 2009 Oct 28.
This tutorial review describes how fibre optic microarrays can be used to create a variety of sensing and measurement systems. This review covers the basics of optical fibres and arrays, the different microarray architectures, and describes a multitude of applications. Such arrays enable multiplexed sensing for a variety of analytes including nucleic acids, vapours, and biomolecules. Polymer-coated fibre arrays can be used for measuring microscopic chemical phenomena, such as corrosion and localized release of biochemicals from cells. In addition, these microarrays can serve as a substrate for fundamental studies of single molecules and single cells. The review covers topics of interest to chemists, biologists, materials scientists, and engineers.
本教程综述介绍了光纤微阵列如何用于创建各种传感和测量系统。本综述涵盖了光纤和阵列的基础知识、不同的微阵列结构,并描述了多种应用。这种阵列能够对多种分析物进行多路复用传感,包括核酸、蒸气和生物分子。聚合物涂层光纤阵列可用于测量微观化学现象,例如腐蚀和细胞内生化物质的局部释放。此外,这些微阵列可用作研究单个分子和单个细胞的基础研究的基底。本综述涵盖了化学家、生物学家、材料科学家和工程师感兴趣的主题。