铱-手性双膦配体催化的 α-芳基-β-取代丙烯酸的高对映选择性氢化反应。
Highly enantioselective hydrogenation of alpha-aryl-beta-substituted acrylic acids catalyzed by Ir-SpinPHOX.
机构信息
Synthetic Organic & Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.
出版信息
Chem Commun (Camb). 2010 Jan 7;46(1):156-8. doi: 10.1039/b919902k. Epub 2009 Nov 24.
DOI:10.1039/b919902k
PMID:20024325
Abstract
The enantioselective hydrogenation of a series of challenging substrates, alpha-aryl-beta-substituted acrylic acids, was realized with high efficiency and enantioselectivity (up to 96%) under the catalysis of Ir(i) complex of Spiro-based P,N ligand, SpinPHOX.
摘要
手性 Ir(i)催化剂 Spiro-PINOX 的高效和对映选择性（高达 96%）实现了一系列具有挑战性的底物，α-芳基-β-取代丙烯酸的对映选择性氢化。
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