铑催化吲哚的[3 + 2]环加成反应。
Rhodium-catalyzed [3 + 2] annulation of indoles.
机构信息
Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
出版信息
J Am Chem Soc. 2010 Jan 20;132(2):440-1. doi: 10.1021/ja9078094.
PMID:20025218
Abstract
An effective Rh(2)(S-DOSP)(4)-catalyzed asymmetric cyclopentannulation of indolyl rings has been developed. Depending on the substitution pattern of the indole, two distinct regioisomeric products can be generated. These studies demonstrate that rhodium-catalyzed reactions of donor/acceptor carbenoids proceeding by means of zwitterionic intermediates can be carried out with very high asymmetric induction.
摘要
已经开发出一种有效的 Rh(2)(S-DOSP)(4)-催化的吲哚环不对称环戊烷化反应。根据吲哚的取代模式，可以生成两种不同的区域异构体产物。这些研究表明，通过两性离子中间体进行的给体/受体卡宾的铑催化反应可以进行非常高的不对称诱导。
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