Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
Org Lett. 2012 Apr 6;14(7):1934-7. doi: 10.1021/ol300632p. Epub 2012 Mar 27.
Asymmetric functionalization of N-heterocycles by vinylcarbenoids in the presence of catalytic amounts of Rh(2)(S-biTISP)(2) has been successfully developed. This bridged dirhodium catalyst not only selectively enforces the reaction to occur at the vinylogous position of the carbenoid but also affords high levels of asymmetric induction.
在催化量 Rh(2)(S-biTISP)(2)的存在下,乙烯型碳烯可以实现 N-杂环的不对称官能化。这种桥连双铑催化剂不仅选择性地促进了碳烯的乙烯基位置的反应,而且还提供了高水平的不对称诱导。