α-亚氨基碳烯与芳环的分子内去芳构化[3 + 2]环加成反应生成 3,4-稠合吲哚骨架。
Intramolecular dearomatizing [3 + 2] annulation of α-imino carbenoids with aryl rings furnishing 3,4-fused indole skeletons.
机构信息
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University , Katsura, Kyoto 615-8510, Japan.
出版信息
J Am Chem Soc. 2014 Feb 12;136(6):2272-5. doi: 10.1021/ja412663a. Epub 2014 Jan 29.
PMID:24437578
Abstract
The rhodium-catalyzed dearomatizing [3 + 2] annulation reaction of 4-(3-arylpropyl)-1,2,3-triazoles is described. It provides a straightforward synthetic pathway from simple 5-aryl-1-alkynes leading to tricyclic 3,4-fused dihydroindoles via the corresponding 1,2,3-triazoles.
摘要
铑催化的 4-(3-芳基丙基)-1,2,3-三唑的去芳构化[3 + 2]环加成反应被描述。它提供了一条从简单的 5-芳基-1-炔烃到通过相应的 1,2,3-三唑得到三环 3,4-稠合二氢吲哚的直接合成途径。
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