Pocklington T, Foster M A
Br J Cancer. 1977 Sep;36(3):369-74. doi: 10.1038/bjc.1977.202.
Electron spin resonance studies have been made of caeruloplasmin and iron transferrin levels in whole blood of healthy controls and patients with a variety of malignant conditions receiving various forms of treatment. A small difference was found in caeruloplasmin level between normal males and females, although normal females receiving contraceptive steroids had an elevated level. No difference was found in iron transferrin level. Various conditions increased the caeruloplasmin and some also decreased the iron transferrin level in patients with malignant disease. These included surgery and the approach of a terminal phase of disease. Once allowance for these factors was made, the remaining small differences in Cu and Fe between patients with either squamous cell carcinoma or breast cancer and controls appeared to have no clinical significance.
对健康对照组以及接受各种治疗的各类恶性疾病患者的全血中铜蓝蛋白和转铁蛋白水平进行了电子自旋共振研究。发现正常男性和女性的铜蓝蛋白水平存在微小差异，不过接受避孕类固醇的正常女性铜蓝蛋白水平有所升高。转铁蛋白水平未发现差异。各种情况会使恶性疾病患者的铜蓝蛋白升高，有些情况还会使转铁蛋白水平降低。这些情况包括手术以及疾病终末期的临近。一旦考虑到这些因素，鳞状细胞癌或乳腺癌患者与对照组之间在铜和铁方面剩余的微小差异似乎并无临床意义。
