Section of Vascular Medicine, Department of General Internal Medicine-Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
J Thromb Haemost. 2010 Mar;8(3):523-32. doi: 10.1111/j.1538-7836.2009.03726.x. Epub 2009 Dec 15.
Even though quality of life (QoL) has become a key component of medical care, there is no instrument available that specifically measures QoL after pulmonary embolism (PE). Recently, the Pulmonary Embolism Quality of Life (PEmb-QoL) Questionnaire has been developed to address this gap.
To evaluate the validity of the PEmb-QoL questionnaire.
We distributed the PEmb-QoL questionnaire and the Short Form-36 (SF-36) questionnaire twice among consecutive subjects with a history of objectively confirmed acute PE. Internal consistency reliability, test-retest reliability, convergent validity and criterion validity, and correlations between the PEmb-QoL and clinical patient characteristics were assessed using standard-scale construction techniques.
Ninety participants completed the questionnaires twice. Internal consistency was adequate (Cronbach's alpha 0.62-0.94), as well as test-retest reliability (intra-class correlation coefficients: 0.78-0.94). Furthermore, correlation between the PEmb-QoL questionnaire and the SF-36 questionnaire supported convergent validity. Age, obesity, cardiopulmonary comorbidity, centrally located PE and a family history of venous thromboembolism were shown to be independent determinants of disease-specific QoL.
The PEmb-QoL questionnaire is a reliable instrument to specifically assess QoL following PE, which is helpful in the identification of patients with decreased QoL following acute PE.
尽管生活质量（QoL）已成为医疗保健的关键组成部分，但仍没有专门用于测量肺栓塞（PE）后生活质量的工具。最近，开发了肺栓塞生活质量（PEmb-QoL）问卷来解决这一差距。
评估 PEmb-QoL 问卷的有效性。
我们在连续的有客观证实的急性 PE 病史的受试者中两次分发了 PEmb-QoL 问卷和简短形式 36 项健康调查（SF-36）问卷。使用标准量表构建技术评估内部一致性可靠性、重测信度、收敛有效性和标准有效性，以及 PEmb-QoL 与临床患者特征之间的相关性。
90 名参与者两次完成了问卷。内部一致性足够（Cronbach's alpha 0.62-0.94），重测信度也足够（组内相关系数：0.78-0.94）。此外，PEmb-QoL 问卷与 SF-36 问卷之间的相关性支持收敛有效性。年龄、肥胖、心肺合并症、中央型 PE 和静脉血栓栓塞家族史被证明是疾病特异性 QoL 的独立决定因素。
PEmb-QoL 问卷是一种可靠的工具，可专门评估 PE 后的生活质量，有助于识别急性 PE 后生活质量下降的患者。
