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肺栓塞是一种慢性疾病吗?

Is pulmonary embolism a chronic disease?

作者信息

Gurumurthy Gerard, Reynolds Lianna, de Wit Kerstin, Roberts Lara N, Thachil Jecko

机构信息

University of Manchester, Manchester, UK.

Paediatric Haematology, Royal Manchester Children's Hospital, Manchester, UK.

出版信息

Clin Med (Lond). 2025 May 9;25(4):100325. doi: 10.1016/j.clinme.2025.100325.

DOI:10.1016/j.clinme.2025.100325
PMID:40349931
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12153374/
Abstract

Pulmonary embolism (PE) is often regarded as an acute disorder, yet emerging evidence underscores its chronic trajectory. Many survivors endure long-term complications, including recurrent thrombosis, persistent dyspnoea and psychosocial challenges. These sequelae impair functional capacity and quality of life long after the initial event. To address these issues, we suggest that clinicians should adopt an integrated, multidisciplinary model that includes risk stratification for recurrence, structured follow-up, exercise rehabilitation, and support for psychological challenges. Recognising the potential chronic sequalae of PE ultimately fosters comprehensive care aimed at reducing morbidity and improving long-term outcomes for survivors.

摘要

肺栓塞(PE)通常被视为一种急性疾病,但新出现的证据强调了其慢性病程。许多幸存者会遭受长期并发症,包括复发性血栓形成、持续性呼吸困难和心理社会挑战。这些后遗症在初始事件发生很久之后仍会损害功能能力和生活质量。为了解决这些问题,我们建议临床医生应采用一种综合的多学科模式,包括复发风险分层、结构化随访、运动康复以及应对心理挑战的支持措施。认识到PE潜在的慢性后遗症最终有助于提供全面的护理,旨在降低发病率并改善幸存者的长期预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb2d/12153374/3385c6b0b209/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb2d/12153374/47a4fee48a47/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb2d/12153374/ea64f6e2e90f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb2d/12153374/f6b515282793/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb2d/12153374/3385c6b0b209/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb2d/12153374/47a4fee48a47/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb2d/12153374/ea64f6e2e90f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb2d/12153374/f6b515282793/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb2d/12153374/3385c6b0b209/gr3.jpg

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本文引用的文献

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Front Sports Act Living. 2024 Nov 20;6:1477562. doi: 10.3389/fspor.2024.1477562. eCollection 2024.
2
The Attend-PE model: A feasibility study of a structured follow-up care model for patients with pulmonary embolism.Attend-PE 模式:肺栓塞患者结构化随访护理模式的可行性研究。
Thromb Res. 2024 Oct;242:109133. doi: 10.1016/j.thromres.2024.109133. Epub 2024 Aug 24.
3
Development of an international standard set of outcome measures for patients with venous thromboembolism: an International Consortium for Health Outcomes Measurement consensus recommendation.
开发一套国际通用的静脉血栓栓塞症患者结局测量指标集:国际健康结局测量联合会共识推荐。
Lancet Haematol. 2022 Sep;9(9):e698-e706. doi: 10.1016/S2352-3026(22)00215-0.
4
2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.2022年欧洲心脏病学会/欧洲呼吸学会肺动脉高压诊断和治疗指南。
Eur Heart J. 2022 Oct 11;43(38):3618-3731. doi: 10.1093/eurheartj/ehac237.
5
Post-Pulmonary Embolism Syndrome and Functional Outcomes after Acute Pulmonary Embolism.急性肺栓塞后的肺栓塞后综合征及功能转归
Semin Thromb Hemost. 2023 Nov;49(8):848-860. doi: 10.1055/s-0042-1749659. Epub 2022 Jul 12.
6
Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease.接受抗凝治疗的静脉血栓栓塞症患者出血风险的管理:ISTH SSC 血栓形成疾病预测和诊断变量小组委员会的报告。
J Thromb Haemost. 2022 Aug;20(8):1910-1919. doi: 10.1111/jth.15776. Epub 2022 Jun 23.
7
Evaluation of patients' experience and related qualitative outcomes in venous thromboembolism: A scoping review.评价静脉血栓栓塞症患者的体验及相关定性结局:范围综述。
J Thromb Haemost. 2022 Oct;20(10):2323-2341. doi: 10.1111/jth.15788. Epub 2022 Jul 18.
8
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Communication at diagnosis of venous thromboembolism: Lasting impact of verbal and nonverbal provider communication on patients.静脉血栓栓塞症诊断时的沟通:医护人员言语和非言语沟通对患者的长期影响。
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Risk of a permanent work-related disability pension after incident venous thromboembolism in Denmark: A population-based cohort study.丹麦人群队列研究:事件性静脉血栓栓塞后永久性与工作相关残疾抚恤金的风险。
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