Mehdizadeh Kasra, Salehi Maryam Mohseni, Moosavi Jamal, Mohebbi Bahram, Klok Frederikus A, Bikdeli Behnood, Shafe Omid, Pouraliakbar Hamidreza, Alizadehasl Azin, Farrashi Melody, Kaviani Raheleh, Mehrvarz Farzaneh, Rashidi Farid, Talakoob Hamed, Bakhshandeh Hooman, Sadeghipour Parham
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Res Pract Thromb Haemost. 2023 Apr 1;7(3):100145. doi: 10.1016/j.rpth.2023.100145. eCollection 2023 Mar.
The Pulmonary Embolism Quality of Life (PEmb-QoL) questionnaire is the first disease-specific scale for assessing the quality of life in patients with a history of pulmonary embolism (PE).
To assess the cross-cultural validity and reliability of the disease-specific PEmb-QoL questionnaire.
The Persian version was prepared through the forward and backward translation of the English questionnaire. Six months after the diagnosis of acute PE, consecutive Persian-speaking patients were asked to complete the PEmb-QoL, the generic 36-item Short Form (SF-36) questionnaires and undertake a 6-minute walk test (6MWT). Acceptability was assessed via item missing rate, reproducibility by the test-retest method, and internal consistency reliability by Cronbach's α and McDonald's ω coefficients. Convergence validity was assessed using the Spearman rank correlation between scores of PEmb-QoL, SF-36, and 6MWT. The questionnaire structure was evaluated through exploratory factor analysis.
Ninety-six patients with a confirmed diagnosis of PE completed the questionnaires. The Persian version of PEmb-QoL had good internal consistency (α = 0.95, 3-factor ω = 0.96), inter-item correlation (0.3-0.62), item-total correlation (0.38-0.71), reproducibility (test-retest ICC with 25 participants = 0.92-0.99), and good discriminant validity. Convergence validity was confirmed by the moderate-to-high correlations between PEmb-QoL and SF-36 scores, and a good correlation between the "limitation in daily activities" dimension of the PEmb-QoL questionnaire and 6MWT results. Exploratory factor analysis suggested a 3-component structure with functional (items 1h, 4b-5d, 6, 8, 9i, and 9j), symptoms (1b-h, 7, and 8), and emotional (5a, 6, and 9a-h) components.
The Persian version of the PEmb-QoL questionnaire is valid and reliable for measuring the disease-specific quality of life in patients with PE.
肺栓塞生活质量（PEmb-QoL）问卷是首个用于评估有肺栓塞（PE）病史患者生活质量的疾病特异性量表。
评估疾病特异性PEmb-QoL问卷的跨文化效度和信度。
通过对英文问卷进行正向和反向翻译来编制波斯语版本。在急性PE诊断6个月后，连续招募说波斯语的患者，要求他们完成PEmb-QoL、通用的36项简短形式（SF-36）问卷，并进行6分钟步行试验（6MWT）。通过项目缺失率评估可接受性，通过重测法评估可重复性，通过Cronbach's α系数和McDonald's ω系数评估内部一致性信度。使用PEmb-QoL、SF-36和6MWT得分之间的Spearman等级相关性评估收敛效度。通过探索性因素分析评估问卷结构。
96例确诊为PE的患者完成了问卷。PEmb-QoL的波斯语版本具有良好的内部一致性（α = 0.95，三因素ω = 0.96）、项目间相关性（0.3 - 0.62）、项目与总分相关性（0.38 - 0.71）、可重复性（25名参与者的重测组内相关系数 = 0.92 - 0.99）以及良好的判别效度。PEmb-QoL与SF-36得分之间的中等到高度相关性，以及PEmb-QoL问卷的“日常活动受限”维度与6MWT结果之间的良好相关性证实了收敛效度。探索性因素分析表明存在一个由功能（项目1h、4b - 5d、6、8、9i和9j）、症状（1b - h、7和8）和情感（5a、6和9a - h）组成部分的三成分结构。
PEmb-QoL问卷的波斯语版本对于测量PE患者的疾病特异性生活质量是有效且可靠的。
