Epidemiology, Faculty of Medicine, University of Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany.
Institute for medical Information Processing, Biometry and Epidemiology (IBE), LMU München, Munich, Germany.
Qual Life Res. 2022 Jul;31(7):2235-2245. doi: 10.1007/s11136-022-03120-3. Epub 2022 Mar 14.
The Pulmonary Embolism Quality of Life (PEmb-QoL) questionnaire is the only existing disease-specific instrument for measuring quality of life after pulmonary embolism (PE). It includes six dimensions: frequency of complaints, limitations in activities of daily living, work-related problems, social limitations, intensity of complaints and emotional complaints. The present study aimed to determine the psychometric properties including responsiveness and structural validity of the German version.
The analysis used data from participants of the LEA cohort study at University Hospital Augsburg. The PEmb-QoL was administered via postal surveys 3, 6 and 12 months post-PE. Internal consistency and test-retest reliability were evaluated by calculating Cronbach's alpha and intra-class correlation coefficients (ICC). Standardized response means (SRM) were calculated for investigating responsiveness. For evaluating the fit of the factor structure, confirmatory factor analysis (CFA) was conducted.
Overall, we used data from 299 patients 3 months after PE. Cronbach's alpha (0.87-0.97) and ICC (0.53-0.90) were in an acceptable to good range. SRM scores showed good responsiveness of all dimensions. CFA revealed the four-factor model including one general factor to have a good model fit.
Despite existing floor effect, most standard criteria of reliability and validity were met and indications for appropriateness of the PEmb-QoL summary score could be found. Apart from some restrictions concerning the factor structure and the dimension of social limitations, our results support the use of the PEmb-QoL questionnaire for evaluating PE-specific quality of life. Future studies should seek replication in different samples to ensure generalizability of the findings.
肺栓塞生活质量问卷（PEmb-QoL）是唯一用于测量肺栓塞（PE）后生活质量的特定疾病工具。它包括六个维度：抱怨频率、日常生活活动受限、与工作相关的问题、社会限制、抱怨强度和情绪抱怨。本研究旨在确定德国版本的心理测量特性，包括反应度和结构有效性。
分析使用了奥格斯堡大学医院 LEA 队列研究参与者的数据。PEmb-QoL 通过邮寄调查在 PE 后 3、6 和 12 个月进行。通过计算 Cronbach's alpha 和组内相关系数（ICC）评估内部一致性和重测信度。为了研究反应性，计算了标准化反应均值（SRM）。为了评估因子结构的拟合度，进行了验证性因子分析（CFA）。
总体而言，我们使用了 299 名 PE 后 3 个月患者的数据。Cronbach's alpha（0.87-0.97）和 ICC（0.53-0.90）处于可接受到良好的范围内。SRM 评分显示所有维度均具有良好的反应性。CFA 显示四因素模型包括一个总因素具有良好的模型拟合度。
尽管存在地板效应，但可靠性和有效性的大多数标准标准都得到了满足，并且可以发现 PEmb-QoL 综合评分的适当性。除了因子结构和社会限制维度的一些限制外，我们的结果支持使用 PEmb-QoL 问卷评估 PE 特定的生活质量。未来的研究应在不同的样本中寻求复制，以确保研究结果的可推广性。
