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1985年至1989年美国陆军年轻成年人中HIV血清转化趋势。美国陆军逆转录病毒研究小组。

Trends of HIV seroconversion among young adults in the US Army, 1985 to 1989. US Army Retrovirus Research Group.

作者信息

McNeil J G, Brundage J F, Gardner L I, Wann Z F, Renzullo P O, Redfield R R, Burke D S, Miller R N

机构信息

Department of Epidemiology, Walter Reed Army Institute of Research, Washington, DC 20307-5100.

出版信息

JAMA. 1991 Apr 3;265(13):1709-14.

PMID:2002572
Abstract

Because soldiers in the US Army are recurrently tested for the presence of antibody to the human immunodeficiency virus (HIV), HIV seroconversion rates can be directly measured. From November 1985 through October 1989, 429 HIV seroconversions were detected among 718,780 soldiers who contributed 1,088,447 person-years of follow-up time (HIV seroconversion rate, 0.39 per 1000 person-years). Period-specific seroconversion rates declined significantly from 0.49 per 1000 person-years (November 1985 through October 1987) to 0.33 per 1000 person-years (November 1987 through October 1988) to 0.29 per 1000 person-years (November 1988 through October 1989). The HIV seroconversion risk among active-duty soldiers was significantly associated with race/ethnic group, age, gender, and marital status. Based on these trends, we estimate that approximately 220 soldiers (95% confidence interval, 160 to 297 soldiers) were infected with HIV during 1989 and 1990, with potentially fewer in future years.

摘要

由于美国陆军士兵会定期接受人体免疫缺陷病毒(HIV)抗体检测,所以HIV血清转化率可以直接测量。从1985年11月到1989年10月,在718,780名士兵中检测到429例HIV血清转化,这些士兵提供了1,088,447人年的随访时间(HIV血清转化率为每1000人年0.39例)。特定时期的血清转化率从每1000人年0.49例(1985年11月至1987年10月)显著下降到每1000人年0.33例(1987年11月至1988年10月),再到每1000人年0.29例(1988年11月至1989年10月)。现役士兵中的HIV血清转化风险与种族/族裔群体、年龄、性别和婚姻状况显著相关。基于这些趋势,我们估计在1989年和1990年期间约有220名士兵(95%置信区间为160至297名士兵)感染了HIV,未来几年可能会更少。

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