Child and Adolescent Psychiatry, University of Göttingen, Germany.
Neuropsychologia. 2010 Mar;48(4):1171-7. doi: 10.1016/j.neuropsychologia.2009.12.018. Epub 2009 Dec 21.
Attention-deficit/hyperactivity disorder (ADHD) is a frequent and highly heritable disorder overrepresented in boys. In a recent study investigating boys only, we found that action monitoring deficits as reflected by certain behavioral and electrophysiological parameters were familially driven. As gender may also have an important impact, this was examined in the current study with nonaffected children aged 8-15 years having relatives suffering from ADHD (N=37, 21 female symbol) and with age-matched controls without family history of ADHD (N=33, 11 female symbol). Extending our previous findings that action monitoring is a potential endophenotype for boys with ADHD, familially driven deficits were confirmed independently of gender. Thus, despite sharing the phenotype with controls, nonaffected siblings showed ADHD-like impairments albeit of smaller magnitude. However, girls performed generally more accurately, which in turn may have produced the differences between nonaffected siblings and controls in affective error processing that were not present in our boys-only assessment.
注意缺陷多动障碍（ADHD）是一种常见的、高度遗传性疾病，在男孩中更为常见。在最近一项仅针对男孩的研究中，我们发现，某些行为和电生理参数反映的动作监控缺陷与家族有关。由于性别也可能有重要影响，本研究在 8-15 岁的非患病儿童中进行，这些儿童的亲属患有 ADHD（N=37，21 名女性符号），并与无 ADHD 家族史的年龄匹配对照（N=33，11 名女性符号）。扩展我们之前的发现，动作监控是 ADHD 男孩的一个潜在的表现型，无论性别如何，家族驱动的缺陷都得到了证实。因此，尽管与对照组具有相同的表型，非患病的兄弟姐妹表现出 ADHD 样的损伤，尽管程度较小。然而，女孩通常表现得更准确，这反过来可能导致了非患病兄弟姐妹和对照组在情感错误处理方面的差异，而这种差异在我们仅对男孩的评估中并不存在。
