Department of Medicine, New York Medical College, Valhalla, USA.
Am J Ther. 2011 May;18(3):e78-80. doi: 10.1097/MJT.0b013e3181c6c0c2.
Psoriasis is a papulosquamous disease of multifactorial etiology. A combination of genetic and environmental agents is implicated in its pathogenesis. A variety of triggers, including infection, stress, and medications, have been recognized as precipitants of this disease. Nonsteroidal anti-inflammatory drugs, beta-blockers, lithium, synthetic antimalarials, and gold are the most common drugs implicated in precipitating psoriasis. We report a patient with psoriasis induced by initiation of losartan therapy, which resolved with discontinuation of the drug. The Naranjo adverse drug reaction probability scale score indicated that the association between losartan use and psoriasis was probable.
银屑病是一种多因素病因的丘疹鳞屑性疾病。遗传和环境因素的组合被认为与其发病机制有关。多种诱因,包括感染、压力和药物,已被认为是诱发这种疾病的原因。非甾体抗炎药、β受体阻滞剂、锂、合成抗疟药和金是最常见的诱发银屑病的药物。我们报告了一例由开始使用氯沙坦治疗引起的银屑病患者,停药后病情缓解。Naranjo 药物不良反应概率量表评分表明氯沙坦的使用与银屑病之间存在可能的关联。