Abel E A, DiCicco L M, Orenberg E K, Fraki J E, Farber E M
J Am Acad Dermatol. 1986 Nov;15(5 Pt 1):1007-22. doi: 10.1016/s0190-9622(86)70265-x.
Drugs that have been associated with the precipitation or exacerbation of psoriasis include lithium, beta adrenergic receptor blocking agents, and antimalarials. The withdrawal of corticosteroids has been reported to activate pustular psoriasis. Nonsteroidal anti-inflammatory drugs, such as indomethacin, have recently been reported to exacerbate psoriasis, although additional well-controlled studies are still needed. Drugs used for treatment of psoriasis will sometimes cause a flare because of irritation, phototoxicity, or hypersensitivity reaction resulting in a Koebner phenomenon. Because psoriasis is a very complex disease and its activity is often unpredictable, clinical studies on adverse drug effects on psoriasis have been difficult to conduct. This review evaluates clinical, histologic, and biochemical evidence in the literature for drug-associated onset or exacerbation of psoriasis.
与银屑病的诱发或加重相关的药物包括锂盐、β肾上腺素能受体阻滞剂和抗疟药。据报道，停用皮质类固醇会引发脓疱型银屑病。近期有报道称，非甾体类抗炎药（如吲哚美辛）会加重银屑病，不过仍需要更多严格对照的研究。用于治疗银屑病的药物有时会因刺激、光毒性或过敏反应导致同形反应而引发病情加重。由于银屑病是一种非常复杂的疾病，其病情活动往往不可预测，因此关于药物对银屑病不良影响的临床研究一直难以开展。本综述评估了文献中有关药物相关性银屑病发病或病情加重的临床、组织学和生化证据。
